Ebook: Hedgehog-Gli Signaling in Human Disease
- Tags: Cancer Research, Developmental Biology, Human Genetics
- Series: Molecular Biology Intelligence Unit
- Year: 2006
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Content:
Front Matter....Pages i-xiii
How the Hedgehog Outfoxed the Crab....Pages 1-22
The Patched Receptor....Pages 23-33
Making a Morphogenetic Gradient....Pages 34-40
Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling....Pages 41-52
Mode of PTCH1/Ptch1-Associated Tumor Formation....Pages 53-62
Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse....Pages 63-73
GLI Genes and Their Targets in Epidermal Development and Disease....Pages 74-85
Splitting Hairs....Pages 86-118
Shh Expression in Pulmonary Injury and Disease....Pages 119-128
Human Correlates of GLI3 Function....Pages 129-136
From Oligodactyly to Polydactyly....Pages 137-145
The Genetics of Indian Hedgehog....Pages 146-152
Sonic Hedgehog Signaling in Craniofacial Development....Pages 153-176
Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon....Pages 177-186
Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis....Pages 187-209
Modulating the Hedgehog Pathway in Diseases....Pages 210-214
Hedgehog Signaling in Endodermally Derived Tumors....Pages 215-224
Back Matter....Pages 225-228
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Content:
Front Matter....Pages i-xiii
How the Hedgehog Outfoxed the Crab....Pages 1-22
The Patched Receptor....Pages 23-33
Making a Morphogenetic Gradient....Pages 34-40
Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling....Pages 41-52
Mode of PTCH1/Ptch1-Associated Tumor Formation....Pages 53-62
Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse....Pages 63-73
GLI Genes and Their Targets in Epidermal Development and Disease....Pages 74-85
Splitting Hairs....Pages 86-118
Shh Expression in Pulmonary Injury and Disease....Pages 119-128
Human Correlates of GLI3 Function....Pages 129-136
From Oligodactyly to Polydactyly....Pages 137-145
The Genetics of Indian Hedgehog....Pages 146-152
Sonic Hedgehog Signaling in Craniofacial Development....Pages 153-176
Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon....Pages 177-186
Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis....Pages 187-209
Modulating the Hedgehog Pathway in Diseases....Pages 210-214
Hedgehog Signaling in Endodermally Derived Tumors....Pages 215-224
Back Matter....Pages 225-228
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