Ebook: Proteomics of Spermatogenesis
Author: Dr. G. S. Gupta Ph.D. (auth.)
- Tags: Proteomics, Cell Biology
- Year: 2005
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.
Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest.
"This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm."
Pawan K. Singal
St. Boniface General Hospital Research Center
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.
Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest.
"This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm."
Pawan K. Singal
St. Boniface General Hospital Research Center
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.
Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest.
"This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm."
Pawan K. Singal
St. Boniface General Hospital Research Center
Content:
Front Matter....Pages i-xxvi
Spermatogenesis....Pages 1-20
Paracrine Role of Sertoli Cell....Pages 21-46
Non-Steroidal Signal Molecules in Spermatogenesis....Pages 47-76
Specificity of Retinol, Estrogen and Steroid Linked Proteins....Pages 77-96
Homeostasis of Germ Cells and Apoptosis....Pages 97-110
Nuclear Skeleton Proteins: Non-Histones....Pages 111-136
Nuclear Skeleton Proteins: Chromosomal Basic Proteins....Pages 137-166
Microtubules....Pages 167-190
Microtubule Based Motor Proteins....Pages 191-210
Sex Chromosomal Proteins and Autosomal Homologues....Pages 211-234
Cell Cycle Components....Pages 235-260
Isoproteins in DNA Synthesis....Pages 261-278
DNA Repair and Recombination....Pages 279-302
Transcriptional Control....Pages 303-322
Proteins in Transcriptional Activity of Spermatogenic Cells....Pages 323-346
Transcription Factors Associated with Spermatogenesis....Pages 347-376
Proto-Oncoproteins....Pages 377-404
G Proteins and Associated Signal Transduction Molecules....Pages 405-438
Protein Kinases....Pages 439-492
Protein Phosphatases....Pages 493-512
Ion Channels and Aquaporins....Pages 513-538
Action of Phospholipases....Pages 539-554
Acrosomal Enzymes....Pages 555-584
Acrosomal Proteins (Non-Enzymatic)....Pages 585-602
Actins and Myosins....Pages 603-622
Cell Adhesion Proteins....Pages 623-654
Metalloproteases and Metalloprotease Inhibitors....Pages 655-668
Isoenzymes in Energy Pathways....Pages 669-694
Fibrous Sheath, Dense Fibers, and Plasma Membrane of Sperm....Pages 695-720
Proteins in Antiperoxidation....Pages 721-748
Quality Control of Germ Cell Proteins....Pages 749-776
Cancer Associated Testis Antigens....Pages 777-794
Selective Group of Germ Cell Specific Proteins....Pages 795-810
Sperm Maturation in Epididymis....Pages 811-837
Back Matter....Pages 839-855
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.
Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest.
"This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm."
Pawan K. Singal
St. Boniface General Hospital Research Center
Content:
Front Matter....Pages i-xxvi
Spermatogenesis....Pages 1-20
Paracrine Role of Sertoli Cell....Pages 21-46
Non-Steroidal Signal Molecules in Spermatogenesis....Pages 47-76
Specificity of Retinol, Estrogen and Steroid Linked Proteins....Pages 77-96
Homeostasis of Germ Cells and Apoptosis....Pages 97-110
Nuclear Skeleton Proteins: Non-Histones....Pages 111-136
Nuclear Skeleton Proteins: Chromosomal Basic Proteins....Pages 137-166
Microtubules....Pages 167-190
Microtubule Based Motor Proteins....Pages 191-210
Sex Chromosomal Proteins and Autosomal Homologues....Pages 211-234
Cell Cycle Components....Pages 235-260
Isoproteins in DNA Synthesis....Pages 261-278
DNA Repair and Recombination....Pages 279-302
Transcriptional Control....Pages 303-322
Proteins in Transcriptional Activity of Spermatogenic Cells....Pages 323-346
Transcription Factors Associated with Spermatogenesis....Pages 347-376
Proto-Oncoproteins....Pages 377-404
G Proteins and Associated Signal Transduction Molecules....Pages 405-438
Protein Kinases....Pages 439-492
Protein Phosphatases....Pages 493-512
Ion Channels and Aquaporins....Pages 513-538
Action of Phospholipases....Pages 539-554
Acrosomal Enzymes....Pages 555-584
Acrosomal Proteins (Non-Enzymatic)....Pages 585-602
Actins and Myosins....Pages 603-622
Cell Adhesion Proteins....Pages 623-654
Metalloproteases and Metalloprotease Inhibitors....Pages 655-668
Isoenzymes in Energy Pathways....Pages 669-694
Fibrous Sheath, Dense Fibers, and Plasma Membrane of Sperm....Pages 695-720
Proteins in Antiperoxidation....Pages 721-748
Quality Control of Germ Cell Proteins....Pages 749-776
Cancer Associated Testis Antigens....Pages 777-794
Selective Group of Germ Cell Specific Proteins....Pages 795-810
Sperm Maturation in Epididymis....Pages 811-837
Back Matter....Pages 839-855
....