Ebook: Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid β

This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-ß production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-ß oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ß-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-ß phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-ß, of direct relevance to Alzheimer’s disease.

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This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-? production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-? oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-? on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ?-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-? phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-?, of direct relevance to Alzheimer’s disease.

 

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This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-? production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-? oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-? on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ?-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-? phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-?, of direct relevance to Alzheimer’s disease.

 

Content:
Front Matter....Pages i-xvii
The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and A? Fibrillogenesis....Pages 1-44
Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects....Pages 45-63
Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy....Pages 65-78
?-Secretase, APP and A? in Alzheimer’s Disease....Pages 79-103
The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases....Pages 105-127
Amyloid ? Degradation: A Challenging Task for Brain Peptidases....Pages 129-145
The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage....Pages 147-165
Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar A?....Pages 167-177
Cholesterol and Amyloid ? Fibrillogenesis....Pages 179-202
Alzheimer’s ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding....Pages 203-224
The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease....Pages 225-234
Amyloid-? Metal Interaction and Metal Chelation....Pages 235-254
The Interaction of Amyloid-? with ApoE....Pages 255-272
Clusterin and Alzheimer’s Disease....Pages 273-298
Acetylcholinesterase Interaction with Alzheimer Amyloid ?....Pages 299-317
Membrane Disordering Effects of ?-Amyloid Peptides....Pages 319-337
The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes....Pages 339-349
Amyloid Inhibitors and ?-Sheet Breakers....Pages 351-364
Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation....Pages 365-380
Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimer’s Disease Neurodegeneration....Pages 381-402
Back Matter....Pages 403-409

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This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-? production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-? oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-? on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ?-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-? phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-?, of direct relevance to Alzheimer’s disease.

 

Content:
Front Matter....Pages i-xvii
The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and A? Fibrillogenesis....Pages 1-44
Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects....Pages 45-63
Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy....Pages 65-78
?-Secretase, APP and A? in Alzheimer’s Disease....Pages 79-103
The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases....Pages 105-127
Amyloid ? Degradation: A Challenging Task for Brain Peptidases....Pages 129-145
The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage....Pages 147-165
Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar A?....Pages 167-177
Cholesterol and Amyloid ? Fibrillogenesis....Pages 179-202
Alzheimer’s ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding....Pages 203-224
The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease....Pages 225-234
Amyloid-? Metal Interaction and Metal Chelation....Pages 235-254
The Interaction of Amyloid-? with ApoE....Pages 255-272
Clusterin and Alzheimer’s Disease....Pages 273-298
Acetylcholinesterase Interaction with Alzheimer Amyloid ?....Pages 299-317
Membrane Disordering Effects of ?-Amyloid Peptides....Pages 319-337
The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes....Pages 339-349
Amyloid Inhibitors and ?-Sheet Breakers....Pages 351-364
Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation....Pages 365-380
Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimer’s Disease Neurodegeneration....Pages 381-402
Back Matter....Pages 403-409
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