Ebook: Lysosomes

Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

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Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

---

Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

Content:
Front Matter....Pages i-xii
History and Morphology of the Lysosome....Pages 1-16
Transport of Lysosomal Enzymes....Pages 17-26
Adaptor Proteins in Lysosomal Biogenesis....Pages 27-36
Lysosomal Membrane Proteins....Pages 37-49
Lysosomal Proteases....Pages 50-59
Lysosomal Storage Disorders....Pages 60-73
Lysosomal Transporters and Associated Diseases....Pages 74-81
Neuronal Ceroid-Lipofuscinoses....Pages 82-99
Cholesterol Transport in Lysosomes....Pages 100-111
Therapy of Lysosomal Storage Diseases....Pages 112-129
Lysosomal Proteome and Transcriptome....Pages 130-143
External Lysosomes....Pages 144-155
Membrane Resealing Mediated by Lysosomal Exocytosis....Pages 156-165
Macroautophagy in Mammalian Cells....Pages 166-180
Chaperone-Mediated Autophagy....Pages 181-193
Back Matter....Pages 195-197

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Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

Content:
Front Matter....Pages i-xii
History and Morphology of the Lysosome....Pages 1-16
Transport of Lysosomal Enzymes....Pages 17-26
Adaptor Proteins in Lysosomal Biogenesis....Pages 27-36
Lysosomal Membrane Proteins....Pages 37-49
Lysosomal Proteases....Pages 50-59
Lysosomal Storage Disorders....Pages 60-73
Lysosomal Transporters and Associated Diseases....Pages 74-81
Neuronal Ceroid-Lipofuscinoses....Pages 82-99
Cholesterol Transport in Lysosomes....Pages 100-111
Therapy of Lysosomal Storage Diseases....Pages 112-129
Lysosomal Proteome and Transcriptome....Pages 130-143
External Lysosomes....Pages 144-155
Membrane Resealing Mediated by Lysosomal Exocytosis....Pages 156-165
Macroautophagy in Mammalian Cells....Pages 166-180
Chaperone-Mediated Autophagy....Pages 181-193
Back Matter....Pages 195-197
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