Ebook: Protein Movement Across Membranes

This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.

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This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.

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This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.

Content:
Front Matter....Pages i-x
Protein Translocation Across the Endoplasmic Reticulum Membrane....Pages 1-18
Preprotein Translocation through the Sec Translocon in Bacteria....Pages 19-32
Protein Translocation in Archaea....Pages 33-44
Structure of the SecYEG Protein Translocation Complex....Pages 45-52
Membrane Protein Insertion in Bacteria from a Structural Perspective....Pages 53-70
The Twin-Arginine Transport System....Pages 71-84
Retro-Translocation of Proteins Across the Endoplasmic Reticulum Membrane....Pages 85-94
Chloroplast Protein Targeting....Pages 95-112
The Mitochondrial Protein Import Machinery....Pages 113-124
Import of Proteins into Peroxisomes....Pages 125-134
Back Matter....Pages 135-137

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This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.

Content:
Front Matter....Pages i-x
Protein Translocation Across the Endoplasmic Reticulum Membrane....Pages 1-18
Preprotein Translocation through the Sec Translocon in Bacteria....Pages 19-32
Protein Translocation in Archaea....Pages 33-44
Structure of the SecYEG Protein Translocation Complex....Pages 45-52
Membrane Protein Insertion in Bacteria from a Structural Perspective....Pages 53-70
The Twin-Arginine Transport System....Pages 71-84
Retro-Translocation of Proteins Across the Endoplasmic Reticulum Membrane....Pages 85-94
Chloroplast Protein Targeting....Pages 95-112
The Mitochondrial Protein Import Machinery....Pages 113-124
Import of Proteins into Peroxisomes....Pages 125-134
Back Matter....Pages 135-137
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