Ebook: Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition

Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).

The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

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Content:
Front Matter....Pages i-xxi
EMT Concept and Examples from the Vertebrate Embryo....Pages 1-11
Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development....Pages 12-28
The Neural Crest....Pages 29-39
Epithelial-Mesenchymal Transformation in the Embryonic Heart....Pages 40-55
Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra....Pages 56-76
Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos....Pages 77-100
Change of Epithelial Fate....Pages 101-110
Cutaneous Wound Reepithelialization....Pages 111-134
Epithelial-Mesenchymal Transitions in Human Cancer....Pages 135-159
Structural and Functional Regulation of Desmosomes....Pages 160-177
Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E-Cadherin....Pages 178-190
The Regulation of Catenins in Cancer....Pages 191-202
Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease....Pages 203-214
The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition....Pages 215-235
TGF?-Dependent Epithelial-Mesenchymal Transition....Pages 236-244
The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering....Pages 245-254
Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases....Pages 255-266
Wnt Signaling Networks and Embryonic Patterning....Pages 267-287
Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network....Pages 288-296
Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition....Pages 297-315
Back Matter....Pages 317-323

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Content:
Front Matter....Pages i-xxi
EMT Concept and Examples from the Vertebrate Embryo....Pages 1-11
Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development....Pages 12-28
The Neural Crest....Pages 29-39
Epithelial-Mesenchymal Transformation in the Embryonic Heart....Pages 40-55
Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra....Pages 56-76
Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos....Pages 77-100
Change of Epithelial Fate....Pages 101-110
Cutaneous Wound Reepithelialization....Pages 111-134
Epithelial-Mesenchymal Transitions in Human Cancer....Pages 135-159
Structural and Functional Regulation of Desmosomes....Pages 160-177
Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E-Cadherin....Pages 178-190
The Regulation of Catenins in Cancer....Pages 191-202
Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease....Pages 203-214
The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition....Pages 215-235
TGF?-Dependent Epithelial-Mesenchymal Transition....Pages 236-244
The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering....Pages 245-254
Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases....Pages 255-266
Wnt Signaling Networks and Embryonic Patterning....Pages 267-287
Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network....Pages 288-296
Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition....Pages 297-315
Back Matter....Pages 317-323
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