Ebook: DNA Conformation and Transcription
Author: Takashi Ohyama Ph.D. (auth.)
- Tags: Biochemistry general, Cell Biology, Human Genetics, Molecular Medicine
- Series: Molecular Biology Intelligence Unit
- Year: 2005
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
DNA....Pages 3-17
Sequence-Dependent Variability of B-DNA....Pages 18-34
Front Matter....Pages 35-35
Curved DNA and Prokaryotic Promoters....Pages 37-51
Repression of Transcription by Curved DNA and Nucleoid Protein H-NS....Pages 52-65
Curved DNA and Transcription in Eukaryotes....Pages 66-74
Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription....Pages 75-89
Front Matter....Pages 91-91
Roles for Z-DNA and Double-Stranded RNA in Transcription....Pages 93-104
Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?....Pages 105-126
Nucleic Acid Structures and the Transcription Defects in Fragile X Syndrome and Friedreich’s Ataxia....Pages 127-137
Possible Roles of DNA Supercoiling in Transcription....Pages 138-143
Front Matter....Pages 145-145
Gene Regulation by HMGA and HMGB Chromosomal Proteins and Related Architectural DNA-Binding Proteins....Pages 147-158
Molecular Mechanisms of Male Sex Determination....Pages 159-173
Front Matter....Pages 175-175
The Role of Unusual DNA Structures in Chromatin Organization for Transcription....Pages 177-188
DNA Bendability and Nucleosome Positioning in Transcriptional Regulation....Pages 189-202
Back Matter....Pages 203-211
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
DNA....Pages 3-17
Sequence-Dependent Variability of B-DNA....Pages 18-34
Front Matter....Pages 35-35
Curved DNA and Prokaryotic Promoters....Pages 37-51
Repression of Transcription by Curved DNA and Nucleoid Protein H-NS....Pages 52-65
Curved DNA and Transcription in Eukaryotes....Pages 66-74
Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription....Pages 75-89
Front Matter....Pages 91-91
Roles for Z-DNA and Double-Stranded RNA in Transcription....Pages 93-104
Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?....Pages 105-126
Nucleic Acid Structures and the Transcription Defects in Fragile X Syndrome and Friedreich’s Ataxia....Pages 127-137
Possible Roles of DNA Supercoiling in Transcription....Pages 138-143
Front Matter....Pages 145-145
Gene Regulation by HMGA and HMGB Chromosomal Proteins and Related Architectural DNA-Binding Proteins....Pages 147-158
Molecular Mechanisms of Male Sex Determination....Pages 159-173
Front Matter....Pages 175-175
The Role of Unusual DNA Structures in Chromatin Organization for Transcription....Pages 177-188
DNA Bendability and Nucleosome Positioning in Transcriptional Regulation....Pages 189-202
Back Matter....Pages 203-211
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