Ebook: Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica­ cy of BMPs in almost all crucial developmental events as well as during regenera­ tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti­ lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.

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There is a great interest for biological regeneration of tissues in particular by using growth factors. BMPs are at this time the only growth and differentiation factors discovered with a high potential in inducing regeneration of tissues like bone, cartilage, kidney, brain etc. Other indications for BMPs in clinical medicine have been further explored in laboratories worldwide, including new discoveries in the field of nephrology and oncology (e.g. in renal osteodystrophy, prostate cancer in animals and metastatic breast cancer). In the field of structur/function analysis of BMPs new discoveries have been made improving our understanding of interactions with receptors and antagonists which could become important in designing drugs for preventing and curing diseases like fibrodysplasia ossificans progressiva.
Covering these points the volume will be of interest to both clinicians and basic scientists, in particular to those entering this exciting field.

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There is a great interest for biological regeneration of tissues in particular by using growth factors. BMPs are at this time the only growth and differentiation factors discovered with a high potential in inducing regeneration of tissues like bone, cartilage, kidney, brain etc. Other indications for BMPs in clinical medicine have been further explored in laboratories worldwide, including new discoveries in the field of nephrology and oncology (e.g. in renal osteodystrophy, prostate cancer in animals and metastatic breast cancer). In the field of structur/function analysis of BMPs new discoveries have been made improving our understanding of interactions with receptors and antagonists which could become important in designing drugs for preventing and curing diseases like fibrodysplasia ossificans progressiva.
Covering these points the volume will be of interest to both clinicians and basic scientists, in particular to those entering this exciting field.

Content:
Front Matter....Pages i-xi
Bone morphogenetic proteins and their role in regenerative medicine....Pages 1-8
Bone morphogenetic protein receptors and their nuclear effectors in bone formation....Pages 9-44
Biology of bone morphogenetic proteins....Pages 45-72
Bone morphogenetic proteins in development....Pages 73-108
Bone morphogenetic proteins in articular cartilage repair....Pages 109-132
Craniofacial reconstruction with bone morphogenetic proteins....Pages 133-155
Clinical experience of osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones....Pages 157-162
Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R&D direction....Pages 163-185
Bone morphogenetic proteins and the synovial joints....Pages 187-212
The role of bone morphogenetic proteins in developing and adult kidney....Pages 213-243
Bone morphogenetic proteins in the nervous system....Pages 245-266
Bone morphogenetic proteins and cancer....Pages 267-292
Bone healing: Bone morphogenetic proteins and beyond....Pages 293-305
Back Matter....Pages 305-312

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There is a great interest for biological regeneration of tissues in particular by using growth factors. BMPs are at this time the only growth and differentiation factors discovered with a high potential in inducing regeneration of tissues like bone, cartilage, kidney, brain etc. Other indications for BMPs in clinical medicine have been further explored in laboratories worldwide, including new discoveries in the field of nephrology and oncology (e.g. in renal osteodystrophy, prostate cancer in animals and metastatic breast cancer). In the field of structur/function analysis of BMPs new discoveries have been made improving our understanding of interactions with receptors and antagonists which could become important in designing drugs for preventing and curing diseases like fibrodysplasia ossificans progressiva.
Covering these points the volume will be of interest to both clinicians and basic scientists, in particular to those entering this exciting field.

Content:
Front Matter....Pages i-xi
Bone morphogenetic proteins and their role in regenerative medicine....Pages 1-8
Bone morphogenetic protein receptors and their nuclear effectors in bone formation....Pages 9-44
Biology of bone morphogenetic proteins....Pages 45-72
Bone morphogenetic proteins in development....Pages 73-108
Bone morphogenetic proteins in articular cartilage repair....Pages 109-132
Craniofacial reconstruction with bone morphogenetic proteins....Pages 133-155
Clinical experience of osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones....Pages 157-162
Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R&D direction....Pages 163-185
Bone morphogenetic proteins and the synovial joints....Pages 187-212
The role of bone morphogenetic proteins in developing and adult kidney....Pages 213-243
Bone morphogenetic proteins in the nervous system....Pages 245-266
Bone morphogenetic proteins and cancer....Pages 267-292
Bone healing: Bone morphogenetic proteins and beyond....Pages 293-305
Back Matter....Pages 305-312
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