Ebook: Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

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Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

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Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
The Evolution of Gasotransmitter Biology and Medicine....Pages 3-31
Interactions Between Gasotransmitters....Pages 33-55
Front Matter....Pages 57-57
Nitric Oxide....Pages 59-94
Chemical Interaction of Nitric Oxide With Protein Thiols....Pages 95-107
Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels....Pages 109-122
Interaction of Nitric Oxide and Related Radical Species With KCa Channels....Pages 123-136
Nitric Oxide and Voltage-Gated Ca2+ Channels....Pages 137-155
Interactions of Nitric Oxide and Cardiac Ion Channels....Pages 157-168
Front Matter....Pages 169-183
Synthesis and Metabolism of Carbon Monoxide....Pages 185-185
Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells....Pages 187-203
Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells....Pages 205-218
The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels....Pages 219-230
Carbon Monoxide and Signal Transduction Pathways....Pages 231-247
Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells....Pages 249-258
Front Matter....Pages 259-272
Hydrogen Sulfide Production and Metabolism in Mammalian Tissues....Pages 273-273
Toxicological and Environmental Impacts of Hydrogen Sulfide....Pages 275-292
Hydrogen Sulfide and the Regulation of Neuronal Activities....Pages 293-313
The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor....Pages 315-321
Hydrogen Sulfide and Visceral Smooth Muscle Contractility....Pages 323-332
Front Matter....Pages 333-344
Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells....Pages 273-273
Front Matter....Pages 345-355
Gasotransmitters as a Novel Class of Metabolic Regulators....Pages 357-357
Back Matter....Pages 359-369
....Pages 371-377