Ebook: Cytokines and Joint Injury
- Tags: Immunology, Pharmacology/Toxicology, Orthopedics, Rheumatology, Cell Biology
- Series: Progress in Inflammation Research
- Year: 2004
- Publisher: Birkhäuser Basel
- Edition: 1
- Language: English
- pdf
The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
Content:
Front Matter....Pages i-xi
The role of tumour necrosis factor in rheumatoid arthritis....Pages 1-28
The IL-1 family: The role of IL-1 and IL-18 in inflammation....Pages 29-67
Targeted IL-1 inhibition....Pages 69-87
Is IL-6 a therapeutic target?....Pages 89-106
The clinical use of anti-cytokine therapy in rheumatic diseases....Pages 107-125
Innate response cytokines in inflammatory synovitis: interleukin-15 and interleukin-18....Pages 127-145
IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis....Pages 147-163
Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair....Pages 165-188
The role of proteinases in joint tissue destruction....Pages 189-220
Receptor activator of nuclear factor кB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity....Pages 221-267
Cytokine regulation of bone destruction....Pages 269-289
Back Matter....Pages 291-298
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
Content:
Front Matter....Pages i-xi
The role of tumour necrosis factor in rheumatoid arthritis....Pages 1-28
The IL-1 family: The role of IL-1 and IL-18 in inflammation....Pages 29-67
Targeted IL-1 inhibition....Pages 69-87
Is IL-6 a therapeutic target?....Pages 89-106
The clinical use of anti-cytokine therapy in rheumatic diseases....Pages 107-125
Innate response cytokines in inflammatory synovitis: interleukin-15 and interleukin-18....Pages 127-145
IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis....Pages 147-163
Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair....Pages 165-188
The role of proteinases in joint tissue destruction....Pages 189-220
Receptor activator of nuclear factor кB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity....Pages 221-267
Cytokine regulation of bone destruction....Pages 269-289
Back Matter....Pages 291-298
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