Ebook: Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine

In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available.

This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.

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Content:
Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Practical Molecular Taxonomy of Fungi....Pages 3-14
Genomics of Filamentous Fungi....Pages 15-29
A Molecular Tool Kit for Fungal Biotechnology....Pages 31-39
Transformation Mediated by Agrobacterium tumefaciens ....Pages 41-65
Front Matter....Pages 67-67
Fungal Polyketide Syntheses in the Information Age....Pages 69-96
More Functions for Multifunctional Polyketide Synthases....Pages 97-125
Peptide Synthesis without Ribosomes....Pages 127-162
Isoprenoids: Gene Clusters and Chemical Puzzles....Pages 163-198
Front Matter....Pages 199-199
Heterologous Expression and Protein Secretion in Filamentous Fungi....Pages 201-219
Artificial Evolution of Fungal Proteins....Pages 221-235
Biocatalysis and Biotransformation....Pages 237-306
Organic Acid Production by Filamentous Fungi....Pages 307-340
Flavors and Fragrances....Pages 341-358
Front Matter....Pages 359-359
Human Mycoses: The Role of Molecular Biology....Pages 361-384
Molecular Interactions of Phytopathogens and Hosts....Pages 385-403
Structural and Functional Genomics of Symbiotic Arbuscular Mycorrhizal Fungi....Pages 405-424
Back Matter....Pages 425-445

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Content:
Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Practical Molecular Taxonomy of Fungi....Pages 3-14
Genomics of Filamentous Fungi....Pages 15-29
A Molecular Tool Kit for Fungal Biotechnology....Pages 31-39
Transformation Mediated by Agrobacterium tumefaciens ....Pages 41-65
Front Matter....Pages 67-67
Fungal Polyketide Syntheses in the Information Age....Pages 69-96
More Functions for Multifunctional Polyketide Synthases....Pages 97-125
Peptide Synthesis without Ribosomes....Pages 127-162
Isoprenoids: Gene Clusters and Chemical Puzzles....Pages 163-198
Front Matter....Pages 199-199
Heterologous Expression and Protein Secretion in Filamentous Fungi....Pages 201-219
Artificial Evolution of Fungal Proteins....Pages 221-235
Biocatalysis and Biotransformation....Pages 237-306
Organic Acid Production by Filamentous Fungi....Pages 307-340
Flavors and Fragrances....Pages 341-358
Front Matter....Pages 359-359
Human Mycoses: The Role of Molecular Biology....Pages 361-384
Molecular Interactions of Phytopathogens and Hosts....Pages 385-403
Structural and Functional Genomics of Symbiotic Arbuscular Mycorrhizal Fungi....Pages 405-424
Back Matter....Pages 425-445
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