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The International Hypoxia Symposium convenes biannually to bring together international experts from many fields to explore the state of the art in normal and pathophysiological responses to hypoxia. Representatives from five continents and 32 countries joined together in February 2003 for four days in the dramatic mountains of Banff, Alberta. As editors of the Proceedings of the International Hypoxia Symposia, we strive to maintain a 26 six year tradition of presenting a stimulating blend of clinical and basic science papers focused on hypoxia. Topics covered in 2003 include hibernation and hypoxia, hypoxia and fetal development and new advances in high altitude pathophysiology, oxidative stress and membrane damage, hypoxic regulation of blood flow, heat shock proteins in hypoxia, and future directions in hypoxia research. In 2003 we also had the privilege ofhonoring John W. Severinghaus as a friend, colleague, mentor and inspiration to many in the field. Tom Hornbein's personal tribute to John Severinghaus is the first chapter in this volume, followed by an entertaining update of the history of the discovery of oxygen written by John Severinghaus.








Content:
Front Matter....Pages i-xv
A Tribute to John Wendell Severinghaus....Pages 1-6
Fire-Air and Dephlogistication....Pages 7-19
Mammalian Hibernation....Pages 21-38
Oxygen Conformance Of Cellular Respiration....Pages 39-55
Current Paradigms in Cellular Oxygen Sensing....Pages 57-71
Why is erythropoietin made in the kidney?....Pages 73-87
Hypoxia And High Altitude....Pages 89-115
Hypoxia and Lung Branching Morphogenesis....Pages 117-125
Hypoxia and Rho/Rho-Kinase Signaling....Pages 127-137
Hypoxic Induction of Myocardial Vascularization During Development....Pages 139-149
Role of Cerebral Blood Volume in Acute Mountain Sickness....Pages 151-159
Ventilation, Autonomic Function, Sleep and Erythropoietin....Pages 161-175
Cardiopulmonary-Pulmonary Interactions at High Altitude....Pages 177-189
Oxidative Stress and Aging....Pages 191-200
Radical Dioxygen....Pages 201-221
Hypoxic Regulation of Blood Flow in Humans....Pages 223-236
Hypoxic Regulation of Blood Flow in Humans....Pages 237-248
Hypoxic regulation of blood Flow in humans....Pages 249-262
Turning up the Heat in the Lungs....Pages 263-275
Proteins Involved In Salvage of The Myocardium....Pages 277-291
The No ? K+ Channel Axis in Pulmonary Arterial Hypertension....Pages 293-322
Non-Erythroid Functions of Erythropoietin....Pages 323-330
Peter Hochachka and Oxygen....Pages 331-337
Proposal for Scoring Severity in Chronic Mountain Sickness (Cms)....Pages 339-354
Epidemiological Modeling of Acute Mountain Sickness (AMS)....Pages 355-358
Late Abstracts....Pages 359-363
Back Matter....Pages 365-372



Content:
Front Matter....Pages i-xv
A Tribute to John Wendell Severinghaus....Pages 1-6
Fire-Air and Dephlogistication....Pages 7-19
Mammalian Hibernation....Pages 21-38
Oxygen Conformance Of Cellular Respiration....Pages 39-55
Current Paradigms in Cellular Oxygen Sensing....Pages 57-71
Why is erythropoietin made in the kidney?....Pages 73-87
Hypoxia And High Altitude....Pages 89-115
Hypoxia and Lung Branching Morphogenesis....Pages 117-125
Hypoxia and Rho/Rho-Kinase Signaling....Pages 127-137
Hypoxic Induction of Myocardial Vascularization During Development....Pages 139-149
Role of Cerebral Blood Volume in Acute Mountain Sickness....Pages 151-159
Ventilation, Autonomic Function, Sleep and Erythropoietin....Pages 161-175
Cardiopulmonary-Pulmonary Interactions at High Altitude....Pages 177-189
Oxidative Stress and Aging....Pages 191-200
Radical Dioxygen....Pages 201-221
Hypoxic Regulation of Blood Flow in Humans....Pages 223-236
Hypoxic Regulation of Blood Flow in Humans....Pages 237-248
Hypoxic regulation of blood Flow in humans....Pages 249-262
Turning up the Heat in the Lungs....Pages 263-275
Proteins Involved In Salvage of The Myocardium....Pages 277-291
The No ? K+ Channel Axis in Pulmonary Arterial Hypertension....Pages 293-322
Non-Erythroid Functions of Erythropoietin....Pages 323-330
Peter Hochachka and Oxygen....Pages 331-337
Proposal for Scoring Severity in Chronic Mountain Sickness (Cms)....Pages 339-354
Epidemiological Modeling of Acute Mountain Sickness (AMS)....Pages 355-358
Late Abstracts....Pages 359-363
Back Matter....Pages 365-372
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