Ebook: The Sodium-Hydrogen Exchanger: From Molecule to its Role in Disease
- Tags: Biochemistry general, Pharmacology/Toxicology, Organic Chemistry, Cardiac Surgery
- Year: 2003
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.
This volume contains state-of-the-art reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance.
*Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical.
*Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms.
*Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors.
The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease will be of interest to pharmacologists, physiologists, biochemists, cell and molecular biologists and clinical scientists interested in new therapeutic concepts related to sodium-hydrogen exchange inhibition.
This volume contains state-of-the-art reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance.
*Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical.
*Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms.
*Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors.
The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease will be of interest to pharmacologists, physiologists, biochemists, cell and molecular biologists and clinical scientists interested in new therapeutic concepts related to sodium-hydrogen exchange inhibition.
Content:
Front Matter....Pages i-xxxii
Regulation of Intracellular pH in Mammalian Cells....Pages 1-15
Molecular and Functional Diversity of Mammalian Na+/H+ Exchangers....Pages 17-34
Two Fundamental Regulatory Factors of the Na+/H+ Exchangers....Pages 35-49
Regulation of Expression of the Na+/H+ Exchanger in the Myocardium and Other Tissues....Pages 51-69
Na-H Exchange Function in Colonic Epithelial Cells....Pages 71-90
NhaA Na+/H+ Antiporter. Structure, Mechanism and Function in Homeostasis of Na+ and pH....Pages 91-108
The Use of Transgenic Animal Models to Study Na+/H+ Exchange....Pages 109-122
pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo....Pages 123-136
Na+/H+ Exchanger Activation by Myocardial Stretch....Pages 137-148
The Paradoxical Role of Na+/H+ Exchanger in the Diabetic Heart....Pages 149-158
Role of Na-H Exchanger in Vascular Remodelling in Diabetes....Pages 159-175
The Potential Role of the Na+/H+ Exchanger in Ischemia/Reperfusion Injury of the Central Nervous System....Pages 177-189
Receptor-Mediated Regulation of the Cardiac Sarcolemmal Na+/H+ Exchanger....Pages 191-209
Role of NHE-1 in Cardiac Hypertrophy and Heart Failure....Pages 211-219
Mechanisms Underlying NHE-1 Involvement in Myocardial Ischemic and Reperfusion Injury....Pages 221-237
Chemistry of NHE Inhibitors....Pages 239-253
Development of NHE Inhibitors for Cardiovascular Therapeutics....Pages 255-264
Cardiac Protection by NHE Inhibitors....Pages 265-278
NHE-1 Inhibitors: Potential Application in Cardiac Surgery....Pages 279-290
NHE-1 Inhibition: A Potential New Treatment for Resuscitation from Cardiac Arrest....Pages 291-308
Back Matter....Pages 309-317
This volume contains state-of-the-art reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance.
*Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical.
*Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms.
*Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors.
The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease will be of interest to pharmacologists, physiologists, biochemists, cell and molecular biologists and clinical scientists interested in new therapeutic concepts related to sodium-hydrogen exchange inhibition.
Content:
Front Matter....Pages i-xxxii
Regulation of Intracellular pH in Mammalian Cells....Pages 1-15
Molecular and Functional Diversity of Mammalian Na+/H+ Exchangers....Pages 17-34
Two Fundamental Regulatory Factors of the Na+/H+ Exchangers....Pages 35-49
Regulation of Expression of the Na+/H+ Exchanger in the Myocardium and Other Tissues....Pages 51-69
Na-H Exchange Function in Colonic Epithelial Cells....Pages 71-90
NhaA Na+/H+ Antiporter. Structure, Mechanism and Function in Homeostasis of Na+ and pH....Pages 91-108
The Use of Transgenic Animal Models to Study Na+/H+ Exchange....Pages 109-122
pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo....Pages 123-136
Na+/H+ Exchanger Activation by Myocardial Stretch....Pages 137-148
The Paradoxical Role of Na+/H+ Exchanger in the Diabetic Heart....Pages 149-158
Role of Na-H Exchanger in Vascular Remodelling in Diabetes....Pages 159-175
The Potential Role of the Na+/H+ Exchanger in Ischemia/Reperfusion Injury of the Central Nervous System....Pages 177-189
Receptor-Mediated Regulation of the Cardiac Sarcolemmal Na+/H+ Exchanger....Pages 191-209
Role of NHE-1 in Cardiac Hypertrophy and Heart Failure....Pages 211-219
Mechanisms Underlying NHE-1 Involvement in Myocardial Ischemic and Reperfusion Injury....Pages 221-237
Chemistry of NHE Inhibitors....Pages 239-253
Development of NHE Inhibitors for Cardiovascular Therapeutics....Pages 255-264
Cardiac Protection by NHE Inhibitors....Pages 265-278
NHE-1 Inhibitors: Potential Application in Cardiac Surgery....Pages 279-290
NHE-1 Inhibition: A Potential New Treatment for Resuscitation from Cardiac Arrest....Pages 291-308
Back Matter....Pages 309-317
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