Ebook: Genome Evolution: Gene and Genome Duplications and the Origin of Novel Gene Functions
- Tags: Evolutionary Biology, Human Genetics, Biochemistry general
- Year: 2003
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances.
This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation.
This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances.
This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation.
This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances.
This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation.
This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
Content:
Front Matter....Pages i-xv
Gene duplication and other evolutionary strategies: from the RNA world to the future....Pages 1-17
Major transitions in evolution by genome fusions: from prokaryotes to eukaryotes, metazoans, bilaterians and vertebrates....Pages 19-25
Detection of gene duplications and block duplications in eukaryotic genomes....Pages 27-34
The evolutionary demography of duplicate genes....Pages 35-44
Functional evolution in the ancestral lineage of vertebrates or when genomic complexity was wagging its morphological tail....Pages 45-52
Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates....Pages 53-63
Are all fishes ancient polyploids?....Pages 65-73
More genes in vertebrates?....Pages 75-84
2R or not 2R: Testing hypotheses of genome duplication in early vertebrates....Pages 85-93
The 2R hypothesis and the human genome sequence....Pages 95-110
Introns in, introns out in plant gene families: a genomic approach of the dynamics of gene structure....Pages 111-116
Investigating ancient duplication events in the Arabidopsis genome....Pages 117-129
Crystallin genes: specialization by changes in gene regulation may precede gene duplication....Pages 131-137
Evolution of signal transduction by gene and genome duplication in fish....Pages 139-150
The role of gene duplication in the evolution and function of the vertebrate Dlx/distal-less bigene clusters....Pages 151-159
Dopamine receptors for every species: Gene duplications and functional diversification in Craniates....Pages 161-176
Nuclear receptors are markers of animal genome evolution....Pages 177-184
The fates of zebrafish Hox gene duplicates....Pages 185-194
Phylogenetic analysis of the mammalian Hoxc8 non-coding region....Pages 195-199
Maximum likelihood methods for detecting adaptive evolution after gene duplication....Pages 201-212
Approach of the functional evolution of duplicated genes in Saccharomyces cerevisiae using a new classification method based on protein-protein interaction data....Pages 213-224
Development gene networks and evolution....Pages 225-234
Back Matter....Pages 235-237
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances.
This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation.
This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
Content:
Front Matter....Pages i-xv
Gene duplication and other evolutionary strategies: from the RNA world to the future....Pages 1-17
Major transitions in evolution by genome fusions: from prokaryotes to eukaryotes, metazoans, bilaterians and vertebrates....Pages 19-25
Detection of gene duplications and block duplications in eukaryotic genomes....Pages 27-34
The evolutionary demography of duplicate genes....Pages 35-44
Functional evolution in the ancestral lineage of vertebrates or when genomic complexity was wagging its morphological tail....Pages 45-52
Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates....Pages 53-63
Are all fishes ancient polyploids?....Pages 65-73
More genes in vertebrates?....Pages 75-84
2R or not 2R: Testing hypotheses of genome duplication in early vertebrates....Pages 85-93
The 2R hypothesis and the human genome sequence....Pages 95-110
Introns in, introns out in plant gene families: a genomic approach of the dynamics of gene structure....Pages 111-116
Investigating ancient duplication events in the Arabidopsis genome....Pages 117-129
Crystallin genes: specialization by changes in gene regulation may precede gene duplication....Pages 131-137
Evolution of signal transduction by gene and genome duplication in fish....Pages 139-150
The role of gene duplication in the evolution and function of the vertebrate Dlx/distal-less bigene clusters....Pages 151-159
Dopamine receptors for every species: Gene duplications and functional diversification in Craniates....Pages 161-176
Nuclear receptors are markers of animal genome evolution....Pages 177-184
The fates of zebrafish Hox gene duplicates....Pages 185-194
Phylogenetic analysis of the mammalian Hoxc8 non-coding region....Pages 195-199
Maximum likelihood methods for detecting adaptive evolution after gene duplication....Pages 201-212
Approach of the functional evolution of duplicated genes in Saccharomyces cerevisiae using a new classification method based on protein-protein interaction data....Pages 213-224
Development gene networks and evolution....Pages 225-234
Back Matter....Pages 235-237
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