Ebook: Transposable Elements: A Guide to the Perplexed and the Novice With Appendices on RNAi, Chromatin Remodeling and Gene Tagging

OY (])PONEOYLI TOIA YTA IIOAAOI OKOEOJII Many fail to grasp what they have seen, and cannot judge what they have learned, ErKYPEOYLI OYL1E MA®ONTEE ITINOEKOYIT although they tell themselves they know. EQYTOJII L1E L10KEOYLI Heraclitus of Ephesus, 500 BC " ... everyone that is not speckled and C~T~v: N,;~, 'T,ji~ ,~~~N ,tuN '= spotted among the goats and brown among the sheep, that shall be counted ~~N N,n =,~, c~w=== c,m stolen with me." Genesis Chapter 30 From Heraclitus of Ephesus and later philosophers, we can deduce that observation of natural phenomena, even when keen and accurate, will not result in meaningful knowledge unless combined with analysis of the mind; just as analysis of the mind without acquaintance with natural phenomena will not suffice to grasp the perceivable world. Only familiarity with phenomena combined with mental analysis will lead to additional knowledge. The citation from Genesis, Chapter 30, is part of an unusual story. It tells how Jacob received, as payment for his service to Laban, the bulk of Laban's herds. By agreement, Jacob was to receive "only" the newborn speckled and spotted goats and the newborn brown sheep that differed completely from their parents. Did Jacob know that there was instability (transposable elements?) in the pigmentation of Laban's herd? It is reasonable to assume that Jacob combined his keen observation with analysis of his mind in order to predict the outcome: most of the newborns were indeed speckled, spotted or brown.

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There are two major classes of Transposable Elements: Class I elements that are mobilized with an RNA intermediate (retrotransposons), and Class II elements that lack such an intermediate. This book provides a historical background and fully describes all known transposable elements, the modes of their transposition and the utilization of these elements in medicine, genetics, and crop improvement. It is the only text that is targeted at a wide range of readers and can be comprehended also by the novice in this field.

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There are two major classes of Transposable Elements: Class I elements that are mobilized with an RNA intermediate (retrotransposons), and Class II elements that lack such an intermediate. This book provides a historical background and fully describes all known transposable elements, the modes of their transposition and the utilization of these elements in medicine, genetics, and crop improvement. It is the only text that is targeted at a wide range of readers and can be comprehended also by the novice in this field.
Content:
Front Matter....Pages i-xiii
Introduction....Pages 1-3
Historical Background....Pages 5-23
Bacterial Insertion Sequences....Pages 25-73
Retrotransposons....Pages 75-157
Telomeres and Transposable Elements....Pages 159-162
Class II Transposable Elements in Eukaryotes....Pages 163-257
Epilogue....Pages 259-260
Appendices....Pages 261-282
References....Pages 283-321
Back Matter....Pages 323-335

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There are two major classes of Transposable Elements: Class I elements that are mobilized with an RNA intermediate (retrotransposons), and Class II elements that lack such an intermediate. This book provides a historical background and fully describes all known transposable elements, the modes of their transposition and the utilization of these elements in medicine, genetics, and crop improvement. It is the only text that is targeted at a wide range of readers and can be comprehended also by the novice in this field.
Content:
Front Matter....Pages i-xiii
Introduction....Pages 1-3
Historical Background....Pages 5-23
Bacterial Insertion Sequences....Pages 25-73
Retrotransposons....Pages 75-157
Telomeres and Transposable Elements....Pages 159-162
Class II Transposable Elements in Eukaryotes....Pages 163-257
Epilogue....Pages 259-260
Appendices....Pages 261-282
References....Pages 283-321
Back Matter....Pages 323-335
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