Ebook: PAS Proteins: Regulators and Sensors of Development and Physiology
- Tags: Biochemistry general, Human Genetics, Medical Microbiology, Neurosciences, Oncology
- Year: 2003
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.
Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.
PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.
Content:
Front Matter....Pages i-xiii
Structure of the PAS Fold and Signal Transduction Mechanisms....Pages 1-16
Signal Transduction in Prokaryotic PAS Domains....Pages 17-50
bHLH-PAS Proteins in C. Elegans ....Pages 51-68
Drosophila bHLH-PAS Developmental Regulatory Proteins....Pages 69-108
Methoprene-Tolerant, A PAS Gene Critical for Juvenile Hormone Signaling in Drosophila Melanogaster ....Pages 109-132
The P160 Family of Steroid Hormone Receptor Coactivators....Pages 133-147
The AH Receptor....Pages 149-182
The HIF-1 Family of bHLH-PAS Proteins: Master Regulators of Oxygen Homeostasis....Pages 183-204
Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes....Pages 205-230
PAS Proteins in the Mammalian Circadian Clock....Pages 231-252
Back Matter....Pages 253-263
Content:
Front Matter....Pages i-xiii
Structure of the PAS Fold and Signal Transduction Mechanisms....Pages 1-16
Signal Transduction in Prokaryotic PAS Domains....Pages 17-50
bHLH-PAS Proteins in C. Elegans ....Pages 51-68
Drosophila bHLH-PAS Developmental Regulatory Proteins....Pages 69-108
Methoprene-Tolerant, A PAS Gene Critical for Juvenile Hormone Signaling in Drosophila Melanogaster ....Pages 109-132
The P160 Family of Steroid Hormone Receptor Coactivators....Pages 133-147
The AH Receptor....Pages 149-182
The HIF-1 Family of bHLH-PAS Proteins: Master Regulators of Oxygen Homeostasis....Pages 183-204
Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes....Pages 205-230
PAS Proteins in the Mammalian Circadian Clock....Pages 231-252
Back Matter....Pages 253-263
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