Ebook: Molecular Mechanisms of Programmed Cell Death

The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz, and John E. Sulston for their seminal discoveries concerning "genetic regulation of organ development and programmed cell death." This clearly marked the prime importance of understanding the molecular mechanisms controlling cell death. The 1 st International Symposium on Programmed Cell Death was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. A number of key issues in apoptosis were discussed at the meeting, and progress in major areas of apopto­ sis research was summarized by expert participants at the meeting and published by Plenum Publishing Corporation as a book entitled Programmed Cell Death. In the last six years, we have witnessed a real explosion in our knowledge on how cells undergo apoptosis, thereby participating in various developmental and pathophysiological processes. At this ever­ exciting time, we organized the 2nd International Symposium on Programmed Cell Death.

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This volume presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. Top scientists from around the world wrote on current progresses to help establish and/or strengthen communications between scientists from the West and those in Asia.

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This volume presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. Top scientists from around the world wrote on current progresses to help establish and/or strengthen communications between scientists from the West and those in Asia.
Content:
Front Matter....Pages i-x
Akt and Bcl-xL Are Independent Regulators of the Mitochondrial Cell Death Pathways....Pages 1-8
Thyroid Hormone-Induced Apoptosis during Amphibian Metamorphosis....Pages 9-19
The Endoplasmic Reticulum Stress Response in Health and Disease....Pages 21-36
The Role of the PI3K Pathway in Anti-IgM (Anti-µ) -Sensitive and -Resistant B-cell Lymphomas....Pages 37-47
Signaling for Inducible Fas-Resistance in Primary B Lymphocytes....Pages 49-66
Apoptosis and Autoimmune Diseases....Pages 67-78
Oxidative Stress and Thymocyte Apoptosis....Pages 79-93
Activation-Induced Cell Death and T Helper Subset Differentiation....Pages 95-104
The Bax -/- Bak -/- Mouse: a Model for Apoptosis....Pages 105-112
Novel Transcriptional Regulatory Pathways of IL-3-Dependent Survival Responses....Pages 113-122
MAP-1 Is a Putative Ligand for the Multidomain Proapoptotic Protein Bax....Pages 123-130
The Mechanisms and Significance of Apoptotic Cell-Mediated Immune Regulation....Pages 131-143
Neuroprotection against Apoptosis....Pages 145-154
Apoptosis, Cancer, and Cancer Therapy....Pages 155-169
DNA Fragmentation in Mammalian Apoptosis and Tissue Homeostasis....Pages 171-183
Ubiquitin and Intracellular Aggregation....Pages 185-193
The Mechanism of Apoptosis Regulation by IAP Antagonist Smac/DIABLO....Pages 195-211
Integration of TNF-a Signaling: Crosstalk between IKK, JNK, and Caspases....Pages 213-219
Back Matter....Pages 221-229

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This volume presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. Top scientists from around the world wrote on current progresses to help establish and/or strengthen communications between scientists from the West and those in Asia.
Content:
Front Matter....Pages i-x
Akt and Bcl-xL Are Independent Regulators of the Mitochondrial Cell Death Pathways....Pages 1-8
Thyroid Hormone-Induced Apoptosis during Amphibian Metamorphosis....Pages 9-19
The Endoplasmic Reticulum Stress Response in Health and Disease....Pages 21-36
The Role of the PI3K Pathway in Anti-IgM (Anti-µ) -Sensitive and -Resistant B-cell Lymphomas....Pages 37-47
Signaling for Inducible Fas-Resistance in Primary B Lymphocytes....Pages 49-66
Apoptosis and Autoimmune Diseases....Pages 67-78
Oxidative Stress and Thymocyte Apoptosis....Pages 79-93
Activation-Induced Cell Death and T Helper Subset Differentiation....Pages 95-104
The Bax -/- Bak -/- Mouse: a Model for Apoptosis....Pages 105-112
Novel Transcriptional Regulatory Pathways of IL-3-Dependent Survival Responses....Pages 113-122
MAP-1 Is a Putative Ligand for the Multidomain Proapoptotic Protein Bax....Pages 123-130
The Mechanisms and Significance of Apoptotic Cell-Mediated Immune Regulation....Pages 131-143
Neuroprotection against Apoptosis....Pages 145-154
Apoptosis, Cancer, and Cancer Therapy....Pages 155-169
DNA Fragmentation in Mammalian Apoptosis and Tissue Homeostasis....Pages 171-183
Ubiquitin and Intracellular Aggregation....Pages 185-193
The Mechanism of Apoptosis Regulation by IAP Antagonist Smac/DIABLO....Pages 195-211
Integration of TNF-a Signaling: Crosstalk between IKK, JNK, and Caspases....Pages 213-219
Back Matter....Pages 221-229
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