Ebook: Nuclear Factor кB: Regulation and Role in Disease
- Tags: Immunology, Animal Anatomy / Morphology / Histology, Animal Biochemistry, Pharmacy, Cancer Research
- Year: 2003
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.
Content:
Front Matter....Pages i-xi
Activators and Target Genes of Rel/NF-кB Transcription Factors....Pages 1-48
NF-?B Activation by Tumor Necrosis Factor and Interleukin-1....Pages 49-67
NF-?B Activation by Card Proteins....Pages 69-88
Viruses as Intruders in the Rel/NF-?B Signaling Pathway....Pages 89-113
The IкB Kinase (IKK) Complex....Pages 115-135
The Role of Ubiquitin In NF-кB Signaling....Pages 137-158
New Insights into the Regulation of Nf-кB....Pages 159-176
The Structural Biology of NF-?B....Pages 177-198
Tools to Interfere with NF-?B Activation....Pages 199-219
Regulation of NF-кB by Glucocorticoids....Pages 221-239
Genetic Analysis of NF-?B-Dependent Signaling Pathways in Mammalian Cells....Pages 241-264
Delineation of NF-кB Signaling by Gene Targeting....Pages 265-294
The Role of NF-?B in Inflammatory Diseases....Pages 295-323
NF-кB in Genetic Disorders....Pages 325-334
NF-кB in the Vascular System....Pages 335-351
NF-?B in T-Lymphocyte Biology....Pages 353-371
NF-кB in the Nervous System....Pages 373-392
NF-?B in Oncogenesis and As a Target for Cancer Therapy....Pages 393-408
Control of Immunity by Rel Proteins in Drosophila....Pages 409-421
Back Matter....Pages 423-426
Content:
Front Matter....Pages i-xi
Activators and Target Genes of Rel/NF-кB Transcription Factors....Pages 1-48
NF-?B Activation by Tumor Necrosis Factor and Interleukin-1....Pages 49-67
NF-?B Activation by Card Proteins....Pages 69-88
Viruses as Intruders in the Rel/NF-?B Signaling Pathway....Pages 89-113
The IкB Kinase (IKK) Complex....Pages 115-135
The Role of Ubiquitin In NF-кB Signaling....Pages 137-158
New Insights into the Regulation of Nf-кB....Pages 159-176
The Structural Biology of NF-?B....Pages 177-198
Tools to Interfere with NF-?B Activation....Pages 199-219
Regulation of NF-кB by Glucocorticoids....Pages 221-239
Genetic Analysis of NF-?B-Dependent Signaling Pathways in Mammalian Cells....Pages 241-264
Delineation of NF-кB Signaling by Gene Targeting....Pages 265-294
The Role of NF-?B in Inflammatory Diseases....Pages 295-323
NF-кB in Genetic Disorders....Pages 325-334
NF-кB in the Vascular System....Pages 335-351
NF-?B in T-Lymphocyte Biology....Pages 353-371
NF-кB in the Nervous System....Pages 373-392
NF-?B in Oncogenesis and As a Target for Cancer Therapy....Pages 393-408
Control of Immunity by Rel Proteins in Drosophila....Pages 409-421
Back Matter....Pages 423-426
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