Ebook: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999. The mission of this meeting was to bring together senior and junior investigators to both announce and examine their recent advancements in cutting-edge research on the roles and actions of lipid mediators and their impact in human physiology and disease pathogenesis. The meeting focused on new concepts in these areas of interest to both clinicians and researchers. The program included several outstanding plenary lectures and presentations by leading experts in the fields of cancer and inflammation. In addition, the Boston meeting presented three Young Investigator awards, one in each of the major focus areas. The meeting was exciting and proved to be very memorable. The program was developed with an emphasis on recent advances in molecular and of lipid mediators relevant in cellular mechanisims involved in the formation and actions inflammation and cancer. Plenary lectures were presented by Prof. Bengt Sammuelsson (Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel Laureate in Chemistry). Both of these plenary lectures were held on Day 1, which set an exciting tone for this meeting. Immediately following these plenary lectures, three simultaneous breakout sessions were held, one of inflammation, a second on cancer and synthesis of novel inhibitors, and a third on enzymes-lipoxygenases/cyclooxygenases and inhibitors.

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Content:
Front Matter....Pages i-xvii
Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis....Pages 3-7
Functional coupling between Phospholipase a2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways....Pages 9-13
Cytosolic Phospholipase A2a Interacts With Microtubules....Pages 15-19
Group IV Cytosolic Phospholipase A2(Pla2) Function:Insights from the Knockout Mouse....Pages 21-24
Investigation Into the Involvement of Phospholipases A2 and Map Kinases in Modulation of Aa Release and Cell Growth in A549 Cells....Pages 25-31
Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells....Pages 33-40
Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecificallylabeled Arachidonic Acids....Pages 41-46
Sequence Determinants For The Positional Specificity Of Lipoxygenases....Pages 49-53
Regulation Of Leukotriene C4 Synthase Gene Expression By Sp1 And Sp3 In Mononuclear Phagocytes....Pages 55-60
Pgg211r-Hpete and 15r/S-Hpete are Formed From Different Conformers of Arachidonic Acid in the Prostaglandin Endoperoxide H Synthase-1 Cyclooxygenase Site....Pages 61-66
Suppression of Cyclooxygenase-2 Gene Transcription by Humulon....Pages 67-72
Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-induced Diabetic Rats.....Pages 73-77
Inhibition of Ultraviolet Light B-Induced Cutaneous Inflammation by A Specific Cyclooxygenase-2 Inhibitor....Pages 79-83
Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells....Pages 85-92
Down-regulation of 5-lipdxygenase activity and leukotriene production by prolonged exposure to Lipopolysaccharide....Pages 93-99
Endothelial cox-2 induction by hypdxia liberates 6-keto-pgf1a, a potent epithelial Secretagogue....Pages 101-105
Substrate Down Regulation of 12lipdxygenase in Human Platelets....Pages 107-112
Calcium Binding to 5-Lipdxygenase....Pages 113-116
Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma....Pages 117-121
Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells....Pages 123-126
15-Lipdxygenase-1 Overexpression in Prostate Adenocarcinoma....Pages 127-131
Characterization Of Epidermal 12(S) And 12(R) Lipdxygenases....Pages 133-145
Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in Cns Injury....Pages 147-153
Intracellular Activation and Induction of 12-lipdxygenase in Mouse Peritoneal Macrophages....Pages 155-160
Epidermis-Type Lipdxygenases....Pages 161-164
Manganese Lipoxygenase Has A Mononuclear Redox Center....Pages 165-170
Cyclooxygenase-2 In Human Pathological Disease....Pages 171-176
Leukotriene D4-Induced Calcium Signaling in Human Intestinal Epithelial Cells....Pages 177-184
Do Leukotrienes Increase Cell Viability in Human Intestinal Epithelial Cells?....Pages 187-191
Aspirin-Triggered 15-Epi-Lipdxin A4Biosynthesis in Rat Liver Cells....Pages 193-198
Anti-Leukotrienes as Novel Anti-Inflammatory Treatments in Asthma....Pages 199-209
Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Modulate Adhesion Molecule Expression on Human Leukocytes in Whole Blood and Inhibit Neutrophil-Endothelial Cell Adhesion....Pages 211-216
Mechanisms of Active Intestinal Inflammation and Potential Down-Regulation Via Lipdxins....Pages 217-221
Interactions Between 5-Oxo-Ete and Chemokines in Stimulating Eosinophils....Pages 223-228
Structure and Function of Human Nad+-Linked 15-Hydroxyprostaglandin Dehydrogenase....Pages 229-236
Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase....Pages 237-242
Purification and Characterization of Membrane-Bound Prostaglandin E Synthase from Bovine Hearts....Pages 245-250
cDNA Cloning and Mutagenesis Study of Liver-Type Prostaglandin F Synthase, and Identification of the Prostaglandin F Producing Cells in the Liver....Pages 251-256
Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells....Pages 257-262
Effects Of Overexpression Of Prostacyclin Synthase In Vascular Smooth Muscle Cells....Pages 263-268
Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene....Pages 269-274
Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase....Pages 275-280
The Design and Synthesis of Selective Prostaglandin Analogs As Bone Anabolic Agents for the Potential Treatment of Osteoporosis....Pages 281-286
Leukotrienes and the Pulmonary Vascular Bed....Pages 287-291
The Contraction of The Human Pulmonary Artery By Ltc4Is Resistant To Cyslt1Antagonists And Counteracted By Prostacyclin Release....Pages 295-301
Targeted gene disruption of the prostaglandin e2 ep2 receptor....Pages 303-307
Ocular Hypotensive Activity of Prostaglandin F2? (PGF2?) Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Preparation but not Ca+ Signalling in Swiss 3T3 Cells....Pages 309-313
Prostanoid FP Receptor Mediated, Endothelium Dependent Vasodilatation and the Ocular Surface Hyperemic Response to PGF2? and Related Compounds....Pages 315-319
Regulation of Cd36 Expression In Human Melanoma Cells....Pages 321-326
Novel Eicosanoid Activators of Ppary Formed by Raw 264.7 Macrophage Cultures....Pages 327-330
Isoprostane Activation of the Nuclear Hormone Receptor Ppar....Pages 331-336
In Vivo Chemotaxis Using Cho Cells Expressing Human Leukotriene B4 Receptor....Pages 337-342
Mechanism of Inhibition of Novel Cox-2 Inhibitors....Pages 343-349
Chemopreventive Effects of Nimesulide, A Selective Cyclooxygenase-2 Inhibitor, Against Phip-Induced Mammary Carcinogenesis....Pages 351-355
Antitumor Effects of Piroxicam in Spontaneous Canine Invasive Urinary Bladder Cancer, A Relevant Model of Human Invasive Bladder Cancer....Pages 357-361
Cannabimimetic Eicosanoids in Cancer and Inflammation: an Update....Pages 365-369
Acetyl-11-Keto-?-Boswellic Acid (Akba) is Cytotoxic for Meningioma Cells and Inhibits Phosphorylation of the Extracellular-Signal Regulated Kinase 1 and 2....Pages 371-376
Cyclooxygenase-2 Induction in Rat Spinal Cord Injury Mediated By Proinflammatory Tumor Necrosis Factor-A and Interleukin-1....Pages 377-380
Growth Stimulation and Epidermal Growth Factor Receptor Induction in Cyclooxygenase-Overexpressing Human Colon Carcinoma Cells....Pages 381-386
Relationship Between Apoptosis, Angiogenesis And Colon-26 Tumour Growth After Oral Nsaid-Treatment....Pages 387-393
Molecular Mechanisms of Prostate Cancer Cell Death Triggered by Inhibition of Arachidonate 5-Lipdxygenase: Involvement of Fas Death Receptor-Mediated Signals....Pages 397-401
induction of apoptosis in mouse t cells upon peroxisome proliferator-activated receptor gamma (ppar-?) binding....Pages 403-407
Nitration of cytochrome c by peroxynitrite: a putative anti-apoptotic pathway mediated by prostaglandin h2 Synthase (pghs) and nitric oxide (no) synthase....Pages 409-414
Apoptosis In Vascular Smooth Muscle Accompanied By Increases In Arachidonic Acid....Pages 415-420
Sphingolipids In Vascular Biology....Pages 421-425
Cyclooxygenase-2: A Molecular Target For Chemoprevention Of Epithelial Tumors Of Skin And Colon....Pages 427-431
Mk 886 Functions As A Radiomimetic Agent: Genomic Responses Related to Oxidative Stress, The Cell Cycle, Proliferation and Programmed Cell Death in Panc-1 Cells....Pages 433-437
Lps-Induced Synthesis and Release of Pge2in Liver Macrophages: Regulation by Cpla2, Cox-1, Cox-2, and Pge2Synthase....Pages 439-444
13(S)-Hpode Modulates Mitogenic Signal Transduction Through Enhancing The Phosphorylation and Association of Egf Receptor with the Tyrosine Phosphatase Shp-2....Pages 445-448
Ku 70/80 Lupus Autoantigen is the Transcription Factor Induced by Interleukins (Il)-13 and -4 Leading to Induction of 15-Lipdxygenase(15-Lo)In Human Cells....Pages 451-456
Divergence in Intracellular Signaling Between Interleukin-4 (IL -4) And IL-13 in Human Cells Localizes To Monomeric/Dimeric Expression of A Transcription Factor, The Lupus Autoantigen 70/80, Induced by Both Cytokines....Pages 457-462
Role of Phosphatidylethanolamine in G Protein-Coupled Receptor-Associated Signal Transduction....Pages 463-467
Signaling Pathways for Tnfa-Induced Cox-2 Expression: Mediation Through Map Kinases And Nfkb, And Inhibition By Certain Nonsteroidal Anti-Inflammatory Drugs....Pages 469-481
12(S)-Hete, Pleiotropic Functions, Multiple Signaling Pathways....Pages 483-489
Formation of Novel D-Ring and E-Ring Isoprostane-Like Compounds (D41e4-Neuroprostanes)in VivoFrom Docosahexaenoic Acidt....Pages 491-496
Regulation of Cell-Substrate Adhesion by the Lipdxygenase and Cyclooxygenase Branches of Arachidonic Acid Metabolism....Pages 497-502
Development of Enzyme Immunoassays for 5,6-, 8,9-,11,12-, And 14,15- Eets and the Corresponding Dhets....Pages 503-508
Enzyme Immunoassays for 15-F2t Isoprostane-M, an Urinary Biomarker for Oxidant Stress....Pages 509-515
Biphasic Regulation of Leukocyte Trafficking by Lipdxins....Pages 519-524
Pantothenic Acid: an Organ-Specific Pro-Oxidant Vitamin¶....Pages 525-529
Linoleate Diol Synthase and PGH Synthase - A New Gene Family of Fatty Acid Heme Dioxygenases?....Pages 531-536
Eicosanoids regulation of transcription factors in pc-3 prostate cancer cells.....Pages 537-541
Non-Prostaglandin Effects of Aspirin Iii and Salicylate: Inhibition of Integrindependent Human Neutrophil Aggregation and Inflammation in Cox 2- and Nf-Kb (P105)-Knockout Mice....Pages 543-549
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Mice....Pages 551-555
Prostanoids In Health and Disease; Lessons From Receptor-Knockout Mice....Pages 557-561
Back Matter....Pages 563-568
....Pages 571-577