Ebook: Calreticulin: Second Edition

The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the significance of these calcium-binding chaperones. The book is unique in every respect and we are not aware of any other publication focusing on these aspects of endoplasmic reticulum biology. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, the book should be of interest to everyone in the biological sciences.

---

---

Content:
Front Matter....Pages i-xx
Introduction to Calreticulin....Pages 1-8
Biochemical and Molecular Properties of Calreticulin....Pages 9-18
A Chaperone System for Glycoprotein Folding: The Calnexin/Calreticulin Cycle....Pages 19-29
Calnexin, an ER Integral Membrane Chaperone in Health and Disease....Pages 30-37
Sub-Cellular Distribution of Calreticulin....Pages 38-48
Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum....Pages 49-62
Roles of Calreticulin and Calnexin in Myeloperoxidase Synthesis....Pages 63-74
Calreticulin-Mediated Nuclear Protein Export....Pages 75-84
The Role of Calnexin and Calreticulin in MHC Class I Assembly....Pages 85-93
Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology....Pages 94-104
Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease....Pages 105-125
Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER....Pages 126-132
ER Calcium and ER Chaperones: New Players in Apoptosis?....Pages 133-141
Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity....Pages 142-150
A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System....Pages 151-161
Calreticulin and Tumor Suppression....Pages 162-179
Calreticulin’s Role(s) in Autoimmune Disorders....Pages 180-192
Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity....Pages 193-204
Calreticulin Regulation of Lung Endothelial NOS Activity....Pages 205-219
Role of Calreticulin in Leishmania Parasite Secretory Pathway and Pathogenesis....Pages 220-237
The Hookworm Calreticulin Conundrum....Pages 238-247
Calreticulin Deficient Mouse....Pages 248-257
Back Matter....Pages 258-266
....Pages 267-282