Ebook: Hormone Signaling

Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

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Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

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Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Content:
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Protein Phosphorylation and Protein-Protein Interactions....Pages 3-19
Control of Signaling by Tyrosine Phosphatases....Pages 21-36
Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway....Pages 37-53
Front Matter....Pages 55-55
The EGF Receptor Signaling System....Pages 57-79
Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences....Pages 81-99
Front Matter....Pages 101-101
The JAK-STAT Pathway....Pages 103-120
Prolactin and Growth Hormone Receptors....Pages 121-143
Erythropoietin, Thrombopoietin and Leptin Receptors....Pages 145-178
Front Matter....Pages 179-179
G Proteins and G Protein-Coupled Receptors....Pages 181-197
Gonadotropin and TSH Receptors....Pages 199-219
Endothelin G Protein-Coupled Receptors....Pages 221-237
Front Matter....Pages 239-239
Signal Transduction and Structure of Nuclear Receptors....Pages 241-267
Estrogen Receptor Beta....Pages 269-282
Sensors for Metabolic Control....Pages 283-304
Back Matter....Pages 305-314

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Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Content:
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Protein Phosphorylation and Protein-Protein Interactions....Pages 3-19
Control of Signaling by Tyrosine Phosphatases....Pages 21-36
Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway....Pages 37-53
Front Matter....Pages 55-55
The EGF Receptor Signaling System....Pages 57-79
Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences....Pages 81-99
Front Matter....Pages 101-101
The JAK-STAT Pathway....Pages 103-120
Prolactin and Growth Hormone Receptors....Pages 121-143
Erythropoietin, Thrombopoietin and Leptin Receptors....Pages 145-178
Front Matter....Pages 179-179
G Proteins and G Protein-Coupled Receptors....Pages 181-197
Gonadotropin and TSH Receptors....Pages 199-219
Endothelin G Protein-Coupled Receptors....Pages 221-237
Front Matter....Pages 239-239
Signal Transduction and Structure of Nuclear Receptors....Pages 241-267
Estrogen Receptor Beta....Pages 269-282
Sensors for Metabolic Control....Pages 283-304
Back Matter....Pages 305-314
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