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The fourth Chinese Peptide Symposium, hosted by Peking University, was held at Chengdu, China on July 21 25, 1996 with 164 participants, including 45 scientists from abroad, representing 12 countries. The four day conference was both intense and spiritually rewarding. Our goal for CPS 96 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 10 sessions with 55 oral and 78 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand receptor interactions, the chemistry biology interface and challenging problems in peptides. Theenthusiasticcooperationandexcellentcontributionsweregratifying andtheactive response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. James P. Tam and Dr. Jie Cheng Xu were the recipients of ‘The Cathay Award’ sponsored by the H. H. Liu Education Foundation, offered for their seminal contributions in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group).




This volume summarizes the papers presented at the Chinese Peptide Symposium-96. The topics of the Symposium comprised six sections:
  • approach and methods;
  • a molecular diversity-peptide library;
  • conformation of peptides and proteins;
  • structure and design;
  • bioactive peptides; and
  • a chemistry-biology interface.
The contributions were concerned with most aspects of peptides and proteins, including chemistry and biology, along with others related to peptides, such as glycopeptides, peptidomimetics and amino acids. The proceedings reflect recent advances in the fields of peptide and protein chemistry and biology, providing a stimulus for continuing research in these and related fields.


This volume summarizes the papers presented at the Chinese Peptide Symposium-96. The topics of the Symposium comprised six sections:
  • approach and methods;
  • a molecular diversity-peptide library;
  • conformation of peptides and proteins;
  • structure and design;
  • bioactive peptides; and
  • a chemistry-biology interface.
The contributions were concerned with most aspects of peptides and proteins, including chemistry and biology, along with others related to peptides, such as glycopeptides, peptidomimetics and amino acids. The proceedings reflect recent advances in the fields of peptide and protein chemistry and biology, providing a stimulus for continuing research in these and related fields.
Content:
Front Matter....Pages i-xxi
Cyclic peptides from unprotected precursors through ring-chain tautomerism....Pages 3-7
Synthesis of glycopeptides with Lewis antigen or sialyl-Lewisx antigen side chains....Pages 8-11
N-urethane protected carboxyanhydrides (UNCAs) in amino acid and peptide chemistry....Pages 12-14
Immobilization of thermolysin for peptide synthesis with a high activity and stability....Pages 15-16
Synthesis of polypeptide by a thioester method....Pages 17-21
Synthesis of amino acids selectively labelled with stable isotopes for application in peptide synthesis....Pages 22-24
Design and synthesis of fluorinated Phe-Gly dipeptidomimetics....Pages 25-26
New methods for synthesis of bis(cystine) peptide dimers....Pages 27-28
Ligation of laminin fragments onto a PEG dendrimer....Pages 29-30
Design and total synthesis of two peptide analogs of actinomycin D: 5,5?-Val2-AMD and 2,2?-Phe2-AMD....Pages 31-32
2,2-Difluoroboroxazolidin-5-ones: A novel approach to selective side-chain protections of serine and threonine by tert-butyl or benzyl groups....Pages 33-34
Signalling approaches to inhibition of cellular proliferation....Pages 35-36
Facile new method for preparation of optically active protected proline....Pages 37-39
A pragmatic way to cleave acid-resistant resin....Pages 40-41
Phosphonamidate based inhibitors of angiotensin-converting enzyme (ACE)....Pages 42-44
Thionyl chloride-phenol and phosphorus oxychloridephenol could be used as efficient deprotection agents in peptide synthesis....Pages 45-47
Solid phase synthesis of sodium ion channel IS3-4 segment simultaneously using Boc and Fmoc chemistry....Pages 48-49
Influence of pH and water content on enzymatic peptide synthestis in organic solvents....Pages 50-51
Application of the one-bead one-compound combinatorial library method in protein tyrosine kinase and cell surface receptor research....Pages 55-58
Libraries of synthetic glycopeptides in the characterization of the T cell response to tumor associated mucin antigens....Pages 59-62
Fluorescent quenched libraries for monitoring chemical and enzymatic disulfide bond formation and cleavage....Pages 63-66
Simultaneous multiple synthesis by the Multipin™ method: Techniques for multiple handling, high throughput characterization and reaction optimization on solid phase....Pages 67-70
Synthesis and antitumour activities of analogs and segments of Papaver somniferum pollen tridecapeptide....Pages 71-74
Utilization of phage displayed peptides in the purification of genetic engineering products....Pages 75-77
A biologically active peptide isolated from the buckwheat pollen....Pages 78-80
Synthesis and structure-activity relationships of tripeptide mimetic analogs of ACE inhibitors....Pages 81-82
Structure-activity relationship of VIP-PACAP hybrid peptides....Pages 83-85
Design and synthesis of salmon calcitonin analogs....Pages 86-87
Template assembled synthetic peptides (TASP) as receptor mimetics and ‘locked-in’ tertiary folds....Pages 91-93
Conformational studies of peptides spanning the helical sequence in the molten globule ?-lactalbumin....Pages 94-95
Folding intermediate of ?-lactoglobulin with non-native ?-helical conformation....Pages 96-97
DNA topoisomerases 11: Evolution of their ATP binding site and design of new inhibitors....Pages 98-99
Analysis of peptide composition and structure of cytochrome P-450nor2....Pages 100-101
Amphipathic helical potency and its relationship to the biological activity of synthetic calcitonin derivatives....Pages 102-103
DNA-binding characteristics of two analogs of actinomycin D: 5,5?-Val2-AMD and 2,2?-Phe2-AMD....Pages 104-105
A modified soft docking method for proteins and peptides....Pages 106-108
Topographical considerations in de novo design of peptides....Pages 109-110
Anticoagulant activity of synthetic peptides targeting various functional steps of blood clotting....Pages 113-117
A rational approach to de novo design of ?-helical proteins....Pages 118-119
Synthesis of a series of amino acid and peptide-porphyrin derivatives....Pages 120-123
Relaxin: Recent structure and activity studies....Pages 124-125
Novel synthesis of cyclotheonamide B1....Pages 126-127
Identification of superantigen TSST-1 sequence important for induction of T cell proliferation using synthetic peptides and antibody to CD28....Pages 131-133
Analogs of the ? opioid antagonist TIPP with increased lipophilic character....Pages 134-135
Cetrorelix, a potent LHRH-antagonist: Chemistry, pharmacology and clinical data....Pages 136-137
Characterization and identification of growth hormone receptors in snakeheaded fish (Ophiocephalida argus cantor) liver membrane....Pages 138-141
Effect of divalent cations and disulfide reducing agents on the specific binding of growth hormone to snakeheaded fish liver membrane....Pages 142-146
Molecular mechanisms of apoptosis induced by CD3? peptide....Pages 147-149
A common antigenic peptide of several HCV proteins....Pages 150-152
Multivalent synthetic peptide vaccine against schistosomiasis: Preparation of multiple antigenic peptide....Pages 153-154
Synthesis of antigenic peptides for HEV diagnosis....Pages 155-156
Synthesis of a radioiodinated photoreactive MAGE-1 peptide derivative and photoaffinity labeling of cell-associated human leukocyte antigen-A1 molecules....Pages 157-159
Development of highly potent human parathyroid hormone analogs....Pages 160-163
CCK-B receptor activation in human lymphoblastic Jurkat cells results in AP-1 responsive genes activation....Pages 164-165
Enhancement of MAPK activity in rat brain following AVP(4–8) administration....Pages 166-168
Involvement of a G-protein coupled receptor (GPCR) in signal transduction induced by arginine-vasopressin(4–8)....Pages 169-170
Effect of arginine vasopressin AVP(4–8) on CaMKII autophosphorylation and CaM expression in rat brain....Pages 171-172
Synthesis of phosphopeptides as inhibitors of progesterone production....Pages 173-175
Synthesis of DL-2-amino-3-(1,2-dihydro-2-thio-quinolinyl)propionic acid....Pages 176-177
The relationship between hypotensive effect and structure of adrenomedullin....Pages 178-180
The preliminary study of arrhythmias in rats caused by PAMP....Pages 181-183
Synthesis and bioactivity of Hir-CGRP chimeric peptides....Pages 184-186
The cardiovascular effects of YIGSR and RGD containing peptides....Pages 187-189
Studies on the hybrid peptides of fibrinogen fragments....Pages 190-191
The combination and function of YIGSR and YIGSK....Pages 192-193
The relaxation effect of the linkers of APLRV and RGD....Pages 194-195
Studies on the linkers of steroids and peptides....Pages 196-197
A novel series of ETA selective antagonists....Pages 198-199
Design, synthesis and circular dichroism spectroscopy studies on DNA-binding activities of GCN4(226—252) peptide dimer....Pages 200-201
Synthesis, resolution of ?-arnino-?-[4-(1,2-dihydro-2-oxoquinolinyl)] propionic acid and its physiological activity....Pages 202-203
Conformational changes of bovine pancreatic polypeptide (BPP) as it interacts with lipids....Pages 204-205
Preparation and evaluation of microspheres with biodegradable PLGA(50/50) containing an LHRH antagonist....Pages 206-208
Ester exchange reaction between N-phosphoserine and thymidine....Pages 209-212
Cleavage of DNA by N-phosphoserine in histidine aqueous medium....Pages 213-214
RNA cleavage by N-phosphoryl serine in histidine buffer....Pages 215-217
A world-wide web server of protein domain assignment....Pages 218-219
Morphological characterization of peptide vesicle of native protein from Chinese wheat by electron microscopy....Pages 223-225
Non-radioactive determination of phosphoamino acids in peptides and proteins by capillary electrophoresis....Pages 226-228
Purification of a 28kD protein from maize pollen and studies on its properties....Pages 229-230
Synthesis of peptides using a thioredoxin gene fusion expression system: An Application to hirudin....Pages 231-232
Kinetics of self-assembly into oligopeptides from N-phosphoamino acids....Pages 233-234
Inhibition of trypsin by N-phosphoamino acids....Pages 235-236
Conjugation of galactosamine and ricin....Pages 237-238
Back Matter....Pages 239-241
....Pages 242-244
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