Ebook: Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.

---

Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.

---

Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.
Content:
Front Matter....Pages i-xxv
Front Matter....Pages 1-1
From the Breath of Life to Reactive Oxygen Species....Pages 3-31
Chemistry of Reactive Oxygen Species....Pages 33-73
Front Matter....Pages 75-75
The Steady-State Concentrations of Oxygen Radicals in Mitochondria....Pages 77-102
The Role of Transition Metal Ions in Free Radical-Mediated Damage....Pages 103-131
Biochemistry of Redox Signaling in the Activation of Oxidative Stress Genes....Pages 133-153
Regulation of Mammalian Gene Expression by Reactive Oxygen Species....Pages 155-171
Inflammatory Regulation of Manganese Superoxide Dismutase....Pages 173-187
Antioxidant Protection and Ixygen Radical Signaling....Pages 189-218
Front Matter....Pages 219-219
Nitric Oxide Synthase....Pages 221-243
The Chemical Biology of Nitric Oxide....Pages 245-291
Nitroxides as Protectors Against Oxidative Stress....Pages 293-313
Front Matter....Pages 315-315
Stratospheric Ozone and Its Effects on the Biosphere....Pages 317-334
Ozone and Nitrogen Dioxide....Pages 335-366
Dietary Antioxidants and Nutrition....Pages 367-393
Front Matter....Pages 395-395
Xanthine Oxidase in Biology and Medicine....Pages 397-420
Melatonin Antioxidative Protection by Electron Donation....Pages 421-451
Ubiquinol an Endogenous Lipid-Soluble Antioxidant in Animal Tissues....Pages 453-477
Front Matter....Pages 479-479
Sources and Effects of Reactive Oxygen Species in Plants....Pages 481-501
The Production and Use of Reactive Oxidants by Phagocytes....Pages 503-526
Production and Effects of Reactive Oxygen Species by Spermatozoa....Pages 527-541
Front Matter....Pages 479-479
Respiratory Burst Oxidase of Fertilization Peroxidative Mechanisms in Sea Urchin Eggs and Human Phagocytes....Pages 543-555
Brain Chemiluminescence as an Indicator of Oxidative Stress....Pages 557-567
Reactive Oxygen Species and Neuronal Function....Pages 569-589
Front Matter....Pages 591-591
Oxidative Stress and Parkinson’s Disease....Pages 593-608
Alzheimer’s ?-Amyloid Peptide and Free Radical Oxidative Stress....Pages 609-638
Oxidative Pathology in Amyotrophic Lateral Sclerosis....Pages 639-655
Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease....Pages 657-675
Front Matter....Pages 677-677
An Overview of Reactive Oxygen Species....Pages 679-695
Back Matter....Pages 697-707

---

Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.
Content:
Front Matter....Pages i-xxv
Front Matter....Pages 1-1
From the Breath of Life to Reactive Oxygen Species....Pages 3-31
Chemistry of Reactive Oxygen Species....Pages 33-73
Front Matter....Pages 75-75
The Steady-State Concentrations of Oxygen Radicals in Mitochondria....Pages 77-102
The Role of Transition Metal Ions in Free Radical-Mediated Damage....Pages 103-131
Biochemistry of Redox Signaling in the Activation of Oxidative Stress Genes....Pages 133-153
Regulation of Mammalian Gene Expression by Reactive Oxygen Species....Pages 155-171
Inflammatory Regulation of Manganese Superoxide Dismutase....Pages 173-187
Antioxidant Protection and Ixygen Radical Signaling....Pages 189-218
Front Matter....Pages 219-219
Nitric Oxide Synthase....Pages 221-243
The Chemical Biology of Nitric Oxide....Pages 245-291
Nitroxides as Protectors Against Oxidative Stress....Pages 293-313
Front Matter....Pages 315-315
Stratospheric Ozone and Its Effects on the Biosphere....Pages 317-334
Ozone and Nitrogen Dioxide....Pages 335-366
Dietary Antioxidants and Nutrition....Pages 367-393
Front Matter....Pages 395-395
Xanthine Oxidase in Biology and Medicine....Pages 397-420
Melatonin Antioxidative Protection by Electron Donation....Pages 421-451
Ubiquinol an Endogenous Lipid-Soluble Antioxidant in Animal Tissues....Pages 453-477
Front Matter....Pages 479-479
Sources and Effects of Reactive Oxygen Species in Plants....Pages 481-501
The Production and Use of Reactive Oxidants by Phagocytes....Pages 503-526
Production and Effects of Reactive Oxygen Species by Spermatozoa....Pages 527-541
Front Matter....Pages 479-479
Respiratory Burst Oxidase of Fertilization Peroxidative Mechanisms in Sea Urchin Eggs and Human Phagocytes....Pages 543-555
Brain Chemiluminescence as an Indicator of Oxidative Stress....Pages 557-567
Reactive Oxygen Species and Neuronal Function....Pages 569-589
Front Matter....Pages 591-591
Oxidative Stress and Parkinson’s Disease....Pages 593-608
Alzheimer’s ?-Amyloid Peptide and Free Radical Oxidative Stress....Pages 609-638
Oxidative Pathology in Amyotrophic Lateral Sclerosis....Pages 639-655
Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease....Pages 657-675
Front Matter....Pages 677-677
An Overview of Reactive Oxygen Species....Pages 679-695
Back Matter....Pages 697-707
....