Ebook: Herpesviruses and Immunity

Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the current results ofthis interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the devel- ment of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpesviruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. Thisproperty of herpesviruses represents amajor challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.

---

The remarkable ability of herpesviruses to escape immunity brings together the two disciplines of immunology and virology in an inextricable way. Because herpesvirus can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the results of this latest interdisciplinary effort document the interactions between both disciplines. Herpesviruses and Immunity brings together the contributions of world-class herpesvirus virologists and immunologists who summarize their work to recount some of the most exciting current developments in the field of herpes virology.

---

The remarkable ability of herpesviruses to escape immunity brings together the two disciplines of immunology and virology in an inextricable way. Because herpesvirus can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the results of this latest interdisciplinary effort document the interactions between both disciplines. Herpesviruses and Immunity brings together the contributions of world-class herpesvirus virologists and immunologists who summarize their work to recount some of the most exciting current developments in the field of herpes virology.
Content:
Front Matter....Pages i-xx
Evasion and Obstruction....Pages 1-32
Immunopathology of Herpesvirus Infections....Pages 33-51
HSV Gene Expression during Latent Infection and Reactivation....Pages 53-77
T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells....Pages 79-114
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS....Pages 115-147
Immunobiology of Murine Gamma Herpesvirus-68....Pages 149-163
EBV and B Cell Lymphomas....Pages 165-190
Immune Responses to Epstein-Barr Viral Infection....Pages 191-206
EBV Persistence in Vivo ....Pages 207-229
Epstein-Barr Virus Vaccines....Pages 231-246
Inhibition of MHC Class I Function by Cytomegalovirus....Pages 247-264
Cell-Mediated Immunity against Varicella-Zoster Virus....Pages 265-290
Complement Control Proteins of Rhadinoviruses....Pages 291-308
Back Matter....Pages 309-317

---

The remarkable ability of herpesviruses to escape immunity brings together the two disciplines of immunology and virology in an inextricable way. Because herpesvirus can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the results of this latest interdisciplinary effort document the interactions between both disciplines. Herpesviruses and Immunity brings together the contributions of world-class herpesvirus virologists and immunologists who summarize their work to recount some of the most exciting current developments in the field of herpes virology.
Content:
Front Matter....Pages i-xx
Evasion and Obstruction....Pages 1-32
Immunopathology of Herpesvirus Infections....Pages 33-51
HSV Gene Expression during Latent Infection and Reactivation....Pages 53-77
T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells....Pages 79-114
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS....Pages 115-147
Immunobiology of Murine Gamma Herpesvirus-68....Pages 149-163
EBV and B Cell Lymphomas....Pages 165-190
Immune Responses to Epstein-Barr Viral Infection....Pages 191-206
EBV Persistence in Vivo ....Pages 207-229
Epstein-Barr Virus Vaccines....Pages 231-246
Inhibition of MHC Class I Function by Cytomegalovirus....Pages 247-264
Cell-Mediated Immunity against Varicella-Zoster Virus....Pages 265-290
Complement Control Proteins of Rhadinoviruses....Pages 291-308
Back Matter....Pages 309-317
....