Ebook: Bone Morphogenetic Proteins: From Laboratory to Clinical Practice

From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions.

This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

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Content:
Front Matter....Pages i-xii
Biochemistry of bone morphogenetic proteins....Pages 1-18
Prostate-derived factor and growth and differentiation factor-8: newly discovered members of the TGF-? superfamily....Pages 19-30
Bone morphogenetic protein receptors and their nuclear effectors in bone formation....Pages 31-60
Deciphering the binding code of BMP-receptor interaction....Pages 61-85
Biology of bone morphogenetic proteins....Pages 87-119
Preclinical models of recombinant BMP induced healing of orthopedic defects....Pages 121-144
Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healing of closed fractures: evidence based medicine and pre-clinical experience....Pages 145-155
Maxillofacial reconstruction....Pages 157-181
Bone morphogenetic proteins in periodontal regeneration....Pages 183-192
Osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones: clinical experience....Pages 193-205
Evaluation of OP-1 in a rabbit model of lumbar fusions....Pages 207-222
Bone morphogenetic proteins and the synovial joints....Pages 223-248
BMPs in articular cartilage repair....Pages 249-262
The role of bone morphogenetic proteins in kidney development and repair....Pages 263-288
Effects of bone morphogenetic proteins on neural tissues....Pages 289-319
Back Matter....Pages 321-328

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Content:
Front Matter....Pages i-xii
Biochemistry of bone morphogenetic proteins....Pages 1-18
Prostate-derived factor and growth and differentiation factor-8: newly discovered members of the TGF-? superfamily....Pages 19-30
Bone morphogenetic protein receptors and their nuclear effectors in bone formation....Pages 31-60
Deciphering the binding code of BMP-receptor interaction....Pages 61-85
Biology of bone morphogenetic proteins....Pages 87-119
Preclinical models of recombinant BMP induced healing of orthopedic defects....Pages 121-144
Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healing of closed fractures: evidence based medicine and pre-clinical experience....Pages 145-155
Maxillofacial reconstruction....Pages 157-181
Bone morphogenetic proteins in periodontal regeneration....Pages 183-192
Osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones: clinical experience....Pages 193-205
Evaluation of OP-1 in a rabbit model of lumbar fusions....Pages 207-222
Bone morphogenetic proteins and the synovial joints....Pages 223-248
BMPs in articular cartilage repair....Pages 249-262
The role of bone morphogenetic proteins in kidney development and repair....Pages 263-288
Effects of bone morphogenetic proteins on neural tissues....Pages 289-319
Back Matter....Pages 321-328
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