Ebook: Fusion of Biological Membranes and Related Problems

Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view.
Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and eventually directing the biological membrane fusion process (when, where, how, and overcoming the activation energy).
In this latest volume in the renowned Subcellular Biochemistry series, some aspects of fusion of biological membranes as well as related problems are presented. Although not complete, there is a lot of recent information including on virus-induced membrane fusion. The contributors of the chapters are all among the researchers who performed many of the pioneering studies in the field.

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Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view.
Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and eventually directing the biological membrane fusion process (when, where, how, and overcoming the activation energy).
In this latest volume in the renowned Subcellular Biochemistry series, some aspects of fusion of biological membranes as well as related problems are presented. Although not complete, there is a lot of recent information including on virus-induced membrane fusion. The contributors of the chapters are all among the researchers who performed many of the pioneering studies in the field.

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Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view.
Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and eventually directing the biological membrane fusion process (when, where, how, and overcoming the activation energy).
In this latest volume in the renowned Subcellular Biochemistry series, some aspects of fusion of biological membranes as well as related problems are presented. Although not complete, there is a lot of recent information including on virus-induced membrane fusion. The contributors of the chapters are all among the researchers who performed many of the pioneering studies in the field.
Content:
Front Matter....Pages i-xxvii
The Secretory Pathway From History to the State of the Art....Pages 1-38
Neurotoxins as Tools in Dissecting the Exocytic Machinery....Pages 39-72
Annexins and Membrane Fusion....Pages 73-131
The Full Complement of Yeast Ypt/Rab-GTPases and Their Involvement in Exo- and Endocytic Trafficking....Pages 133-173
Possible Roles of Long-chain Fatty Acyl-CoA Esters in the Fusion of Biomembranes....Pages 175-231
Brefeldin A Revealing the Fundamental Principles Governing Membrane Dynamics and Protein Transport....Pages 233-272
Membrane Fusion Events during Nuclear Envelope Assembly....Pages 273-302
Transactions at the Peroxisomal Membrane....Pages 303-322
Neurons, Chromaffin Cells and Membrane Fusion....Pages 323-378
Reversibility in Fusion Protein Conformational Changes The Intriguing Case of Rhabdovirus-Induced Membrane Fusion....Pages 379-408
Specific Roles for Lipids in Virus Fusion and Exit Examples from the Alphaviruses....Pages 409-455
Fusion Mediated by the HIV-1 Envelope Protein....Pages 457-481
Sulfhydryl Involvement in Fusion Mechanisms....Pages 483-514
Back Matter....Pages 515-529

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Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view.
Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and eventually directing the biological membrane fusion process (when, where, how, and overcoming the activation energy).
In this latest volume in the renowned Subcellular Biochemistry series, some aspects of fusion of biological membranes as well as related problems are presented. Although not complete, there is a lot of recent information including on virus-induced membrane fusion. The contributors of the chapters are all among the researchers who performed many of the pioneering studies in the field.
Content:
Front Matter....Pages i-xxvii
The Secretory Pathway From History to the State of the Art....Pages 1-38
Neurotoxins as Tools in Dissecting the Exocytic Machinery....Pages 39-72
Annexins and Membrane Fusion....Pages 73-131
The Full Complement of Yeast Ypt/Rab-GTPases and Their Involvement in Exo- and Endocytic Trafficking....Pages 133-173
Possible Roles of Long-chain Fatty Acyl-CoA Esters in the Fusion of Biomembranes....Pages 175-231
Brefeldin A Revealing the Fundamental Principles Governing Membrane Dynamics and Protein Transport....Pages 233-272
Membrane Fusion Events during Nuclear Envelope Assembly....Pages 273-302
Transactions at the Peroxisomal Membrane....Pages 303-322
Neurons, Chromaffin Cells and Membrane Fusion....Pages 323-378
Reversibility in Fusion Protein Conformational Changes The Intriguing Case of Rhabdovirus-Induced Membrane Fusion....Pages 379-408
Specific Roles for Lipids in Virus Fusion and Exit Examples from the Alphaviruses....Pages 409-455
Fusion Mediated by the HIV-1 Envelope Protein....Pages 457-481
Sulfhydryl Involvement in Fusion Mechanisms....Pages 483-514
Back Matter....Pages 515-529
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