Ebook: Oxygen-Ozone Therapy: A Critical Evaluation

When I was about fifteen, my Biological Seiences teacher, Prof. N. Benacchio, lent me a book by Paul de Kruif "The Microbe Hunters" and I remained fascinated by infectious diseases. I was intrigued by the potency of virulent bacteria which are constantly trying to invade our bodies and often overcome what today we call innate and adoptive immunity. Indeed, shortly after that, I was struck by his tragic death due to peritonitis. Later, while studying medicine (although medical knowledge in the 1950s was almost primordial compared with today), I soon realised how the various biological systems were wonderfully organised but at the same time frail and how our life could end in a few minutes. Slowly it became obvious that our "wellness" was the result of a dynamic and very unstable equilibrium between health and disease. This unstable equilibrium could be broken forever if the body's response could not reverse the pathological state. I stuck a sort ofposter on the wall ofmy room with these three words and connecting arrows: HEALTH~-? DISEASE -? DEATH As I don't believe in another world after death, it became obvious to me that we should make every possible effort not only to delay death, but to try always to shift the equilibrium to the left. In this book, I will try to show that this can be achieved, as a last resort, even with ozonetherapy.

---

This book represents the first serious attempt to explain the fundamental basis of ozonetherapy and is a relevant step towards achieving further progress. Ozone is now considered a real drug and, after reacting with body fluids, releases messengers and activates several mechanisms which are able to elicit multiple biological effects. The therapeutic window has been defined and, contrary to the dogma that `ozone is toxic any way you deal with it', it has been shown that ozone toxicity can be tamed and even totally avoided.

New powerful methodologies have been devised and astonishing clinical results in vascular and infectious diseases have already been achieved. An exciting novelty is the induction of an adaptive response that implies the unsuspected possibility of arresting cell degeneration due to endogenous chronic oxidative stress. However, further basic and controlled clinical studies need to be performed to fully exploit ozone's therapeutic potentials and to establish the real validity of this therapy. Authoritative scientists and clinicians should abandon their prejudice and consider the profound difference between endogenous oxidative stress and the new concept of ozonetherapeutic `shock'. If this happens, we could soon have a simple and inexpensive tool to restore health in millions of patients.

This book has been written in a plain scientific language and can be read by scientists and clinicians, as well as by patients keen on regaining a state of well being.

---

This book represents the first serious attempt to explain the fundamental basis of ozonetherapy and is a relevant step towards achieving further progress. Ozone is now considered a real drug and, after reacting with body fluids, releases messengers and activates several mechanisms which are able to elicit multiple biological effects. The therapeutic window has been defined and, contrary to the dogma that `ozone is toxic any way you deal with it', it has been shown that ozone toxicity can be tamed and even totally avoided.

New powerful methodologies have been devised and astonishing clinical results in vascular and infectious diseases have already been achieved. An exciting novelty is the induction of an adaptive response that implies the unsuspected possibility of arresting cell degeneration due to endogenous chronic oxidative stress. However, further basic and controlled clinical studies need to be performed to fully exploit ozone's therapeutic potentials and to establish the real validity of this therapy. Authoritative scientists and clinicians should abandon their prejudice and consider the profound difference between endogenous oxidative stress and the new concept of ozonetherapeutic `shock'. If this happens, we could soon have a simple and inexpensive tool to restore health in millions of patients.

This book has been written in a plain scientific language and can be read by scientists and clinicians, as well as by patients keen on regaining a state of well being.

Content:
Front Matter....Pages i-xxvii
A Brief Historical Review....Pages 1-5
How I Came to Study Ozonetherapy: An Odyssey with no end in Sight....Pages 7-30
Ozone in Nature....Pages 31-35
Physico-Chemical Properties of Ozone....Pages 37-39
Ozone Toxicity: Biological Risk, Toxicology and First Aid....Pages 41-42
The Ozone Generator....Pages 43-46
How to Check Ozone Concentrations....Pages 47-50
Solubility of Ozone in Water and Preparation of Ozonized Water and Oil....Pages 51-56
Preliminary Basis For Understanding Ozone Reactivity and the Potential Risks of Ozonetherapy....Pages 57-69
How is Oxidative Stress Assessed?....Pages 71-73
Is There Any Justification for Using Ozonetherapy in Human Pathologies Caused or Worsened by Free Radicals?....Pages 75-77
The Antioxidant System and the Defence System Against Ozone....Pages 79-107
How does Ozone Act?....Pages 109-120
What Happens in the Intracellular Environment after Blood Ozonization?....Pages 121-170
Are Blood Lipoproteins Oxidized after Ozonization?....Pages 171-172
How is Ozone Administered ?....Pages 173-187
Extracorporeal Blood Circulation Versus O2-O3 (EBOO)....Pages 189-197
Quasi-Total Body Exposure to O2-O3 (BOEX)....Pages 199-212
Rectal Insufflation of O2-O3 (RI)....Pages 213-222
The Potential Toxicity and Mutagenicity of Ozone....Pages 223-226
Side Effects and Contraindications of Ozonetherapy....Pages 227-231
The Adaptation to Chronic Oxidative Stress (COS)....Pages 233-240
How to Evaluate Ozonetherapy?....Pages 241-242
Ozonetherapy in Various Pathologies....Pages 243-325
How Important is the Placebo Effect in Ozonetherapy?....Pages 327-329
Ozonetheraphy in Dentistry....Pages 331-331
Ozonetheraphy in Cosmetology....Pages 333-335
Ozonetheraphy in Veterinary Medicine....Pages 337-339
Ozone as Doping in Athletes....Pages 341-341
Ozone as a Rejuvenating Agent....Pages 343-345
Ozone as a Drinking Water Disinfectant....Pages 347-348
Ozone Disinfection to Prevent Nosocomial Infections....Pages 349-350
Can Ozone be Useful for Banked Blood or Fresh Frozen Plasma?....Pages 351-352
Is There Any Way to Substitute Ozonization of Blood?....Pages 353-357
Hyperbaric Oxygen Therapy (HOT) Versus Ozonetherapy....Pages 359-362
Acute Care During or after Ozonetherapy....Pages 363-364
Orthodox Medicine Versus Complementary Medicine: A Conflict that may be Resolved with Appropriate Research....Pages 365-368
Does Ozonetherapy Have a Future in Medicine?....Pages 369-374
Appendix: The Optimized Procedure of O3-AHT....Pages 375-380
Back Matter....Pages 381-440

---

This book represents the first serious attempt to explain the fundamental basis of ozonetherapy and is a relevant step towards achieving further progress. Ozone is now considered a real drug and, after reacting with body fluids, releases messengers and activates several mechanisms which are able to elicit multiple biological effects. The therapeutic window has been defined and, contrary to the dogma that `ozone is toxic any way you deal with it', it has been shown that ozone toxicity can be tamed and even totally avoided.

New powerful methodologies have been devised and astonishing clinical results in vascular and infectious diseases have already been achieved. An exciting novelty is the induction of an adaptive response that implies the unsuspected possibility of arresting cell degeneration due to endogenous chronic oxidative stress. However, further basic and controlled clinical studies need to be performed to fully exploit ozone's therapeutic potentials and to establish the real validity of this therapy. Authoritative scientists and clinicians should abandon their prejudice and consider the profound difference between endogenous oxidative stress and the new concept of ozonetherapeutic `shock'. If this happens, we could soon have a simple and inexpensive tool to restore health in millions of patients.

This book has been written in a plain scientific language and can be read by scientists and clinicians, as well as by patients keen on regaining a state of well being.

Content:
Front Matter....Pages i-xxvii
A Brief Historical Review....Pages 1-5
How I Came to Study Ozonetherapy: An Odyssey with no end in Sight....Pages 7-30
Ozone in Nature....Pages 31-35
Physico-Chemical Properties of Ozone....Pages 37-39
Ozone Toxicity: Biological Risk, Toxicology and First Aid....Pages 41-42
The Ozone Generator....Pages 43-46
How to Check Ozone Concentrations....Pages 47-50
Solubility of Ozone in Water and Preparation of Ozonized Water and Oil....Pages 51-56
Preliminary Basis For Understanding Ozone Reactivity and the Potential Risks of Ozonetherapy....Pages 57-69
How is Oxidative Stress Assessed?....Pages 71-73
Is There Any Justification for Using Ozonetherapy in Human Pathologies Caused or Worsened by Free Radicals?....Pages 75-77
The Antioxidant System and the Defence System Against Ozone....Pages 79-107
How does Ozone Act?....Pages 109-120
What Happens in the Intracellular Environment after Blood Ozonization?....Pages 121-170
Are Blood Lipoproteins Oxidized after Ozonization?....Pages 171-172
How is Ozone Administered ?....Pages 173-187
Extracorporeal Blood Circulation Versus O2-O3 (EBOO)....Pages 189-197
Quasi-Total Body Exposure to O2-O3 (BOEX)....Pages 199-212
Rectal Insufflation of O2-O3 (RI)....Pages 213-222
The Potential Toxicity and Mutagenicity of Ozone....Pages 223-226
Side Effects and Contraindications of Ozonetherapy....Pages 227-231
The Adaptation to Chronic Oxidative Stress (COS)....Pages 233-240
How to Evaluate Ozonetherapy?....Pages 241-242
Ozonetherapy in Various Pathologies....Pages 243-325
How Important is the Placebo Effect in Ozonetherapy?....Pages 327-329
Ozonetheraphy in Dentistry....Pages 331-331
Ozonetheraphy in Cosmetology....Pages 333-335
Ozonetheraphy in Veterinary Medicine....Pages 337-339
Ozone as Doping in Athletes....Pages 341-341
Ozone as a Rejuvenating Agent....Pages 343-345
Ozone as a Drinking Water Disinfectant....Pages 347-348
Ozone Disinfection to Prevent Nosocomial Infections....Pages 349-350
Can Ozone be Useful for Banked Blood or Fresh Frozen Plasma?....Pages 351-352
Is There Any Way to Substitute Ozonization of Blood?....Pages 353-357
Hyperbaric Oxygen Therapy (HOT) Versus Ozonetherapy....Pages 359-362
Acute Care During or after Ozonetherapy....Pages 363-364
Orthodox Medicine Versus Complementary Medicine: A Conflict that may be Resolved with Appropriate Research....Pages 365-368
Does Ozonetherapy Have a Future in Medicine?....Pages 369-374
Appendix: The Optimized Procedure of O3-AHT....Pages 375-380
Back Matter....Pages 381-440
....