Ebook: Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic

This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.

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This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.

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This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.
Content:
Front Matter....Pages i-ix
Lymphocyte Development in Neonatal and Adult C-Kit-Deficient (C-Kitw/w) Mice....Pages 1-10
Development of Antigen-Specific Helper T Cell Responses in Vivo....Pages 11-20
Bcl-6 Uncouples B Lymphocyte Proliferation from Differentiation....Pages 21-28
The Role of Vav Proteins in B Cell Responses....Pages 29-34
Traffic Patterns of B Cells and Plasma Cells....Pages 35-41
Lymphocyte Trafic in Lymphoid Organ Neogenesis....Pages 43-48
Regulation of Spleen White Pulp Structure and Function by Lymphotoxin....Pages 49-56
Enzymatic Control of Leukocyte Trafficking: Role of VAP-1....Pages 57-63
Homeostatic Chemokines and the Targeting of Regional Immunity....Pages 65-72
Factors Regulating Naive T Cell Homeostasis....Pages 73-80
IL-7, The thymus, and Naive T Cells....Pages 81-90
Neonates Support “Homeostatic” Proliferation....Pages 91-95
Self-Recognition and the Regulation of Cd4+ T Cell Survival....Pages 97-105
Tcr-Independent Proliferation and Differentiation of Human Cd4+ T Cell Subsets Induced by Cytokines....Pages 107-112
Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence....Pages 113-120
Some Properties of T Cells in Animals....Pages 121-128
Generation and Characterization of Memory Cd4 T Cells....Pages 129-134
T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals....Pages 135-139
Migration of Primary and Memory Cd8 T Cells....Pages 141-146
Cytokines and Memory-Phenotype Cd8+ Cells....Pages 147-153
Antiviral Memory T Cell Responses....Pages 155-164
Homeostatic Proliferation But not The Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R?....Pages 165-175
Irreversible Marking of Dendritic Cells in Vivo....Pages 177-181
Tracking Arterial Smooth Muscle-Specific T Cells in the Inflamed Vasculature....Pages 183-189
Regulation of T Cell Migration Through Formation of Immunological Synapses....Pages 191-201
Two-Photon imaging in Intact Lymphoid Tissue....Pages 203-208
Back Matter....Pages 209-212

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This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.
Content:
Front Matter....Pages i-ix
Lymphocyte Development in Neonatal and Adult C-Kit-Deficient (C-Kitw/w) Mice....Pages 1-10
Development of Antigen-Specific Helper T Cell Responses in Vivo....Pages 11-20
Bcl-6 Uncouples B Lymphocyte Proliferation from Differentiation....Pages 21-28
The Role of Vav Proteins in B Cell Responses....Pages 29-34
Traffic Patterns of B Cells and Plasma Cells....Pages 35-41
Lymphocyte Trafic in Lymphoid Organ Neogenesis....Pages 43-48
Regulation of Spleen White Pulp Structure and Function by Lymphotoxin....Pages 49-56
Enzymatic Control of Leukocyte Trafficking: Role of VAP-1....Pages 57-63
Homeostatic Chemokines and the Targeting of Regional Immunity....Pages 65-72
Factors Regulating Naive T Cell Homeostasis....Pages 73-80
IL-7, The thymus, and Naive T Cells....Pages 81-90
Neonates Support “Homeostatic” Proliferation....Pages 91-95
Self-Recognition and the Regulation of Cd4+ T Cell Survival....Pages 97-105
Tcr-Independent Proliferation and Differentiation of Human Cd4+ T Cell Subsets Induced by Cytokines....Pages 107-112
Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence....Pages 113-120
Some Properties of T Cells in Animals....Pages 121-128
Generation and Characterization of Memory Cd4 T Cells....Pages 129-134
T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals....Pages 135-139
Migration of Primary and Memory Cd8 T Cells....Pages 141-146
Cytokines and Memory-Phenotype Cd8+ Cells....Pages 147-153
Antiviral Memory T Cell Responses....Pages 155-164
Homeostatic Proliferation But not The Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R?....Pages 165-175
Irreversible Marking of Dendritic Cells in Vivo....Pages 177-181
Tracking Arterial Smooth Muscle-Specific T Cells in the Inflamed Vasculature....Pages 183-189
Regulation of T Cell Migration Through Formation of Immunological Synapses....Pages 191-201
Two-Photon imaging in Intact Lymphoid Tissue....Pages 203-208
Back Matter....Pages 209-212
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