Ebook: Peptides Biology and Chemistry: Proceedings of the 1998 Chinese Peptide Symposium July 14–17, 1998, Lanzhou, China

The Fifth Chinese Peptide Symposium, hosted by Lanzhou University, was held at Lanzhou, China July 14-17, 1998, with 156 participants, including 30 scientists from abroad, representing nine countries. The four-day conference was both intense and spiritually rewarding. Our goal for CPS-98 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 8 sessions with 42 oral and 90 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface and challenging problems in peptides. The enthusiastic cooperation and excellent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. Kit Lam of the University of Arizona and Dr. Yun-Hua Ye of Peking University were the recipients of “The Cathay Award” sponsored by the H. H. Liu Education Foundation, offered for their seminal contribution in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group).

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This book represents the achievements of current peptide science research in China over the last two years. The International Chinese Peptide Symposium is an academic meeting held every two years and this 5th meeting (5th CPS-98) was held on July 14-17 1998, in Lanzhou, Gansu, China, hosted by Lanzhou University. The 5th PCS-98 was represented by over 150 participants including 30 scientists from nine countries outside China. This book contains the keynote lectures and the vast majority of the oral presentations. It covers the highest level of Chinese peptide research and as such should be of great interest to any peptide scientist.

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This book represents the achievements of current peptide science research in China over the last two years. The International Chinese Peptide Symposium is an academic meeting held every two years and this 5th meeting (5th CPS-98) was held on July 14-17 1998, in Lanzhou, Gansu, China, hosted by Lanzhou University. The 5th PCS-98 was represented by over 150 participants including 30 scientists from nine countries outside China. This book contains the keynote lectures and the vast majority of the oral presentations. It covers the highest level of Chinese peptide research and as such should be of great interest to any peptide scientist.
Content:
Front Matter....Pages i-xx
Orthogonal ligation of free peptides....Pages 3-13
Solid phase synthesis of peptide aldehydes....Pages 8-13
Investigation of enzyme activity and inhibition in the interior of novel solid supports....Pages 14-20
Immobilization of ?-Chymotrypsin on zeolite for peptide synthesis in organic solvent....Pages 21-25
Preparation of a peptide thioester using a fluoren-9-ylmethoxycarbonyl solid-phase method....Pages 26-29
Application of DEPBT for the synthesis of N-protected peptide alcohols....Pages 30-32
Decomposition of amino acid cupric complex by using tetrahydrothiazole-2-thione for preparation of N?-Boc-N?-Fmoc-L-Lysine....Pages 33-35
Two-step selective formation of three disulfide bridges in the synthesis of ?-Gonotoxin PVIA....Pages 36-39
Design, synthesis and NMR structure of a rigid cyclic peptide template....Pages 43-47
Automated docking of Sch68631 with HCV NS3 protease....Pages 48-50
Molecular modeling of the three-dimensional structure of the human interleukin-11....Pages 51-54
Designing ?-hairpin forming short peptide....Pages 55-58
Anti-tumor activities of papavor somniferum pollen peptides....Pages 59-61
Structural investigation of two pollen peptides by 2 D homonuclear NMR spectroscopy....Pages 62-64
A comparison of three heuristic algorithms for molecular docking....Pages 65-68
Aggregation of a calmodulin-binding peptide....Pages 69-72
Neuropepxide AVP(4–8) playing an indirect neurotrophic role....Pages 75-76
Potent bradykinin antagonists having medical potential....Pages 77-80
Understanding the chemistry and biology of rodent relaxin: Role of the C-peptide....Pages 81-84
Synthesis and biological activity of human calcitonin analogs....Pages 86-88
Enhanced expression of CNDF mRNA in rat brain by administration of AVP(4–8)....Pages 89-91
The synthesis and opioid activities of nociceptin and its fragments....Pages 92-94
The effect of Glu position change on the opioid activity of deltorphin II....Pages 95-97
Study of the relationship between structure and function of HIV-1 gp 41 N terminus fusion peptide....Pages 98-101
Hypotensive activities of nociceptin and its fragments....Pages 102-103
The design and synthesis of endomorphinsand their analogues....Pages 104-107
Neuronal apoptosis induced by ?-amyloid peptides in vitro....Pages 108-111
Studies on the spin-labeling technique on deltorphin II and its analogues....Pages 112-115
Design and synthesis of salmon calcitonin and its analogues....Pages 116-118
Studies on the synthesis and antithrombosis activity of two peptides derived from the molecular-binding site of fibrinogen....Pages 119-123
Synthesis and expression of w-conotoxin MVIIA....Pages 124-125
Studies on the synthetic peptide vaccines against schistosomiasis....Pages 126-128
Studies on the anti-schistosomal synthetic peptide vaccine: Prediction and synthesis of antigenic peptides of Schistosoma paramyosin....Pages 129-133
Construction and expression of a recombinant antibody targeted plasminogen activator....Pages 137-139
Chemical conjugation between haemophilus influenzae type b (hib) polysaccharide and proteins....Pages 140-141
Synthesis of human inhibin fragments, preparation and generation of monoclonal antibodies against human inhibin....Pages 142-144
Design of a ? opioid peptide mimetic based on a topographically constrained cyclic enkephalin....Pages 145-146
Tetrazole cis-amide bond mimetics identify the ?-turn conformation of insect kinin neuropeptides....Pages 147-149
Synthetic studies of farnesyl protein transferase inhibitor pepticinnamin E....Pages 153-157
Novel coupling reagents....Pages 158-162
Pharmacophore model of growth hormone secretagogues....Pages 163-165
Discovery that deltorphin II derivatives are potent melanotropins, putatively active at the Xenopus melanocortin-1 receptor....Pages 166-168
Enzymatic synthesis of phosphopeptides....Pages 169-171
Synthesis of phosphorylated polypeptide by a thioester method....Pages 172-174
Difference between N-phospho-L- and D-methionine in ester exchange reaction with uridine....Pages 177-179
Synthesis of analogs of phosphoamino acids and their biomimic reactions....Pages 180-185
Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides....Pages 186-187
Parallel synthesis of muramyl peptides derivatives....Pages 188-191
?-Cyclodextrin for presentation of bioactive peptides to molecular recognition....Pages 192-197
The C-terminus of ?-opioid receptor does not control DPDPE-induced desensitization....Pages 198-201
Detection of gene expression product of transgenic tobacco by antigenic peptide....Pages 202-209
Advantages of Calcitonin complexed with SA liposome....Pages 210-212
Hypoglycemic effects of insulin sublingual drops containing azone on rats and rabbits....Pages 215-216
Chemo-enzymatic syntheses of eel calcitonin analogs having natural N-linked oligosaccharides....Pages 217-220
Design of specific inhibitors at the ATP binding site of DNA topoisomerases II....Pages 221-223
Applications of optical biosensors to structure-function studies in the EGF/EGF receptor system....Pages 227-229
Experimental study of osteogenic growth peptide promoting bone mass in rat osteoporosis....Pages 230-233
Determination of inhibitory constants for CPA by competitive spectrophotometry....Pages 234-337
Sublingual administration of monomeric insulin— destetrapeptide insulin....Pages 238-242
How to get patent rights to protect your invention in biotechnology....Pages 244-246
Study on peptide maps from milk protein hydrolysates by SE-HPLC....Pages 247-248
Synthesis and solution structures of new chiral enantiomeric peptide nucleic acid (PNA) dimers....Pages 249-251
Study of one type of metallothionein and SZ51 recombinant protein directing and imaging reagent....Pages 252-254
LHRH antagonists: new preclinical and clinical results....Pages 255-257
DNA-binding characteristics of antitumor drug actinomycin D and its analogs....Pages 258-261
Design, synthesis of the peptide analogs of antitumor agent actinomycin D....Pages 262-263
Back Matter....Pages 264-268
....Pages 269-273