Ebook: Cellular Peptidases in Immune Functions and Diseases 2

Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.

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Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Content:
Front Matter....Pages i-xii
Review: The Role of Membrane Peptidase in Immune Functions....Pages 1-24
Structure and Function of Aminopeptidase N....Pages 25-34
Modulation of WNT-5At Eexpression by Actinonin: Linkage of APN to the WNT-Pathway?....Pages 35-41
Enzymatic Activity Is Not A Precondition For The Intracellular Calcium Increase Mediated By mAbs Specific For Aminopeptidase N/CD13....Pages 43-47
Transforming Growth Factor-? Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Monocytes and Monocytic Cell Lines....Pages 49-56
Cell-Cell Contact Between Lymphocytes and Fibroblast-Like Synovioctyes Induces Lymphocytic Expression of Aminopeptidase n/cd13 and Results in Lymphocytic Activation....Pages 57-66
Natural Substrates of Dipeptidyl Peptidase IV....Pages 67-87
Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV....Pages 89-95
Development of a Tertiary-Structure Model of the C-Terminal Domain of DPP IV....Pages 97-101
Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity....Pages 103-109
A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CD26) Activity....Pages 111-115
Potent Inhibitors of Dipeptidyl Peptidase iv and Their Mechanisms of Inhibition....Pages 117-123
N-Terminal HIV-1 Tat Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterization....Pages 125-129
Signal Transduction Events Induced or Affected by Inhibition of the Catalytic Activity of Dipeptidyl Peptidase IV (DP IV, CD26)....Pages 131-137
Specific Inhibitors of Dipeptidyl Peptidase IV Suppress mRNA Expression of DP IV/CD26 and Cytokines....Pages 139-143
Dipeptidyl Peptidase IV in Inflammatory CNS Disease....Pages 145-153
Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease....Pages 155-160
Effects of Nonapeptides Derived From the N-terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) Tat on Suppression of CD26-Dependent T Cell Growth....Pages 161-165
DNA Synthesis in Cultured Human Keratinocytes and Hacat Kerationcytes is Reduced by Specific Inhibition of Dipeptidyl Peptidase IV (CD26) Enzymatic Activity....Pages 167-171
Attractin: A Cub-Family Protease Involved in T Cell-Monocyte/Macrophage Interactions....Pages 173-185
Analogs of Glucose-Dependent Insulinotropic Polypeptide With Increased Dipeptidyl Peptidase IV Resistance....Pages 187-195
Dipeptidyl Peptidase IV (DPP IV, CD26) In Patients With Mental Eating Disorders....Pages 197-204
Matrix Metalloproteinases (MMP-8, -13 and -14) Interact with the Clotting System and Degrade Fibrinogen and Factor XII (Hagemann Factor)....Pages 205-216
The Neprilysin Family in Health and Disease....Pages 217-228
Review: Novel Cysteine Proteases of the Papain Family....Pages 229-240
Development and Validation of Homology Models of Human Cathepsins K, S, H, and F....Pages 241-254
The Function of Propeptide Domains of Cysteine Proteinases....Pages 255-260
Human Cathepsins W and F form A New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-Like Cysteine Proteases....Pages 261-270
Cathepsin K Expression in Human Lung....Pages 271-280
Expression of Cathepsins B and L in Human Lung Epithelial Cells is Regulated by Cytokines....Pages 281-286
Functions of Cathepsin K in Bone Resorption....Pages 287-292
Ceramide as an Activator Lipid of Cathepsin D....Pages 293-303
Human Cathepsin X....Pages 305-315
A Novel Proteolytic Mechanism for Termination of the Ca2+ Signalling Evoked by Proteinase-Activated Receptor-1 (PAR-1) in Rat Astrocytes....Pages 317-322
Natural and Synthetic Inhibitors of The Tumor-Associated Serine Protease Urokinase-Type Plasminogen Activator....Pages 323-329
Processing of Interleukin-18 by Human Vascular Smooth Muscle Cells....Pages 331-341
Review: Peptidases and Peptidase Inhibitors in the Pathogenesis of Diseases....Pages 343-348
The Role of Proteolysis in Alzheimer’s Disease....Pages 349-378
Observing Proteases in Living Cells....Pages 379-390
The Role of Cysteine Proteases in Intracellular Pancreatic Serine Protease Activation....Pages 391-401
Peptidases in the Asthmatic Airways....Pages 403-410
Inactivation of Interleukin-6 by Neutrophil Proteases at Sites of Inflammation....Pages 413-430
Antisense Inhibition of Cathepsin Bina Human Osteosarcoma Cell Line....Pages 431-437
Protease-Protease Inhibitor Balance in the Gastric Mucosa....Pages 439-444
The Role of Bacterial and Host Proteinases in Periodontal Disease....Pages 445-454
Multifunctional Role of Proteases in Rhumatic Diseases....Pages 455-465
Evidence of Proteolytic Activation of Transforming Growth Factor ? in Synovial Fluid....Pages 467-476
Matrix Metalloproteinases and Tace Play A Role in The Pathogenesis of Endometriosis....Pages 477-481
Influence of Proliferation, Differentiation and Dedifferentiation Factors on the Expression of the Lysosomal Cysteine Proteinase Cathepsin L (CL) in Thyroid Cancer Cell Lines....Pages 483-486
Back Matter....Pages 487-495
....Pages 497-522