Ebook: Self-Assembling Peptide Systems in Biology, Medicine and Engineering

One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.

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This is the first ever text on the intrinsic self-assembling behaviour of peptides and the implications of these properties for a broad range of applications. These include protein conformational diseases, the engineering of nanostructured biodegradable and biocompatible polymeric materials with potential applications in tissue engineering, biomedical devices, industrial fluids and personal care products. This new area of endeavour is outlined in a series of 25 articles summarising lectures presented at the first ever meeting on this topic held in Crete in July 1999.
Audience: The articles address generic issues making the text readily amenable to postgraduate students, academics, and research scientists interested in new challenges at the physical sciences - life sciences interface.

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This is the first ever text on the intrinsic self-assembling behaviour of peptides and the implications of these properties for a broad range of applications. These include protein conformational diseases, the engineering of nanostructured biodegradable and biocompatible polymeric materials with potential applications in tissue engineering, biomedical devices, industrial fluids and personal care products. This new area of endeavour is outlined in a series of 25 articles summarising lectures presented at the first ever meeting on this topic held in Crete in July 1999.
Audience: The articles address generic issues making the text readily amenable to postgraduate students, academics, and research scientists interested in new challenges at the physical sciences - life sciences interface.
Content:
Front Matter....Pages i-xii
Exploiting Peptide Self-assembly to Engineer Novel Biopolymers: Tapes, Ribbons, Fibrils and Fibres....Pages 1-17
Ribbon-Like Lamellar Structures from Chain-Folded Polypeptides....Pages 19-33
Design of Self-Assembling Peptides as Catalyst Mimetics Using Synthetic Combinatorial Libraries....Pages 35-45
Thermodynamics of Protein-Protein and Peptide Interactions....Pages 47-64
The Mechanism of Amyloid Formation and Its Links to Human Disease and Biological Evolution....Pages 65-74
Transgenic Plants for Large Scale Production of Peptides and Proteins....Pages 15-85
Assembly Modulation of Channel-Forming Peptides....Pages 87-104
Molecular Casting of Infectious Amyloids, Inorganic and Organic Replication: Nucleation, Conformational Change and Self-Assembly....Pages 105-112
Structure and Stabilisation of Self-Assembling Peptide Filaments....Pages 113-125
Designed Combinatorial Libraries of Novel Amyloid-Like Proteins....Pages 127-138
Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules....Pages 139-160
Amyloid-Like Fibrils from a Peptide-Analogue of the Central Domain of Silkmoth Chorion Proteins....Pages 161-169
Amyloidogenesis of Islet Amyloid Polypeptide (IAPP)....Pages 171-185
Engineering Self-Assembly of Peptides by Amphiphilic 2D Motifs: ?-to-? Transitions of Peptides....Pages 187-205
Model Signal Peptides: Probes of Molecular Interactions During Protein Secretion....Pages 207-220
Structure, Folding and Assembly of Adenovirus Fibers....Pages 221-234
Solving the Structure of Collagen....Pages 235-241
Disulfide Bond Based Self-Assembly of Peptides Leading To Spheroidal Cyclic Trimers....Pages 243-256
A New Circular Helicoid-Type Sequential Oligopeptide carrier for Assembling Multiple Antigenic Peptides....Pages 257-271
Molecular Recognition in the Membrane: Role in the Folding of Membrane Proteins....Pages 273-294
Novel Peptide Nucleic Acids with Improved Solubility and DNA-Binding Ability....Pages 295-309
Chiral Lipid Tubules....Pages 311-321
?Tt-Mechanism in the Design of Self-Assembling Structures....Pages 323-342
Self-assembling Peptide Systems in Biology and Biomedical Engineering....Pages 343-360
Back Matter....Pages 361-364

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This is the first ever text on the intrinsic self-assembling behaviour of peptides and the implications of these properties for a broad range of applications. These include protein conformational diseases, the engineering of nanostructured biodegradable and biocompatible polymeric materials with potential applications in tissue engineering, biomedical devices, industrial fluids and personal care products. This new area of endeavour is outlined in a series of 25 articles summarising lectures presented at the first ever meeting on this topic held in Crete in July 1999.
Audience: The articles address generic issues making the text readily amenable to postgraduate students, academics, and research scientists interested in new challenges at the physical sciences - life sciences interface.
Content:
Front Matter....Pages i-xii
Exploiting Peptide Self-assembly to Engineer Novel Biopolymers: Tapes, Ribbons, Fibrils and Fibres....Pages 1-17
Ribbon-Like Lamellar Structures from Chain-Folded Polypeptides....Pages 19-33
Design of Self-Assembling Peptides as Catalyst Mimetics Using Synthetic Combinatorial Libraries....Pages 35-45
Thermodynamics of Protein-Protein and Peptide Interactions....Pages 47-64
The Mechanism of Amyloid Formation and Its Links to Human Disease and Biological Evolution....Pages 65-74
Transgenic Plants for Large Scale Production of Peptides and Proteins....Pages 15-85
Assembly Modulation of Channel-Forming Peptides....Pages 87-104
Molecular Casting of Infectious Amyloids, Inorganic and Organic Replication: Nucleation, Conformational Change and Self-Assembly....Pages 105-112
Structure and Stabilisation of Self-Assembling Peptide Filaments....Pages 113-125
Designed Combinatorial Libraries of Novel Amyloid-Like Proteins....Pages 127-138
Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules....Pages 139-160
Amyloid-Like Fibrils from a Peptide-Analogue of the Central Domain of Silkmoth Chorion Proteins....Pages 161-169
Amyloidogenesis of Islet Amyloid Polypeptide (IAPP)....Pages 171-185
Engineering Self-Assembly of Peptides by Amphiphilic 2D Motifs: ?-to-? Transitions of Peptides....Pages 187-205
Model Signal Peptides: Probes of Molecular Interactions During Protein Secretion....Pages 207-220
Structure, Folding and Assembly of Adenovirus Fibers....Pages 221-234
Solving the Structure of Collagen....Pages 235-241
Disulfide Bond Based Self-Assembly of Peptides Leading To Spheroidal Cyclic Trimers....Pages 243-256
A New Circular Helicoid-Type Sequential Oligopeptide carrier for Assembling Multiple Antigenic Peptides....Pages 257-271
Molecular Recognition in the Membrane: Role in the Folding of Membrane Proteins....Pages 273-294
Novel Peptide Nucleic Acids with Improved Solubility and DNA-Binding Ability....Pages 295-309
Chiral Lipid Tubules....Pages 311-321
?Tt-Mechanism in the Design of Self-Assembling Structures....Pages 323-342
Self-assembling Peptide Systems in Biology and Biomedical Engineering....Pages 343-360
Back Matter....Pages 361-364
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