Ebook: Membrane Transporters as Drug Targets

Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.

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Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.

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Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Content:
Front Matter....Pages i-xxv
Overview of Membrane Transport....Pages 1-27
Classification of Membrane Transporters....Pages 29-58
Drug Transport and Targeting....Pages 59-88
The Molecular Basis for Hepatobiliary Transport of Organic Cations and Organic Anions....Pages 89-157
Affinity of Drugs to the Different Renal Transporters for Organic Anions and Organic Cations....Pages 159-179
Drug Disposition and Targeting....Pages 181-200
The Mammalian Facilitative Glucose Transporter (GLUT) Family....Pages 201-228
Cationic Amino Acid Transporters (CATs)....Pages 229-249
Electrophysiological Analysis of Renal Na+-Coupled Divalent Anion Transporters....Pages 251-267
Dipeptide Transporters....Pages 269-288
Antigenic Peptide Transporter....Pages 289-312
Nucleoside Transporters of Mammalian Cells....Pages 313-352
Multidrug-Resistance Transporters....Pages 353-386
Transporters for Bile Acids and Organic Anions....Pages 387-439
Molecular and Functional Characteristics of Cloned Human Organic Cation Transporters....Pages 441-469
Organic Anion Transporters....Pages 471-491
Vitamin B12 Transporters....Pages 493-520
Back Matter....Pages 521-530

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Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Content:
Front Matter....Pages i-xxv
Overview of Membrane Transport....Pages 1-27
Classification of Membrane Transporters....Pages 29-58
Drug Transport and Targeting....Pages 59-88
The Molecular Basis for Hepatobiliary Transport of Organic Cations and Organic Anions....Pages 89-157
Affinity of Drugs to the Different Renal Transporters for Organic Anions and Organic Cations....Pages 159-179
Drug Disposition and Targeting....Pages 181-200
The Mammalian Facilitative Glucose Transporter (GLUT) Family....Pages 201-228
Cationic Amino Acid Transporters (CATs)....Pages 229-249
Electrophysiological Analysis of Renal Na+-Coupled Divalent Anion Transporters....Pages 251-267
Dipeptide Transporters....Pages 269-288
Antigenic Peptide Transporter....Pages 289-312
Nucleoside Transporters of Mammalian Cells....Pages 313-352
Multidrug-Resistance Transporters....Pages 353-386
Transporters for Bile Acids and Organic Anions....Pages 387-439
Molecular and Functional Characteristics of Cloned Human Organic Cation Transporters....Pages 441-469
Organic Anion Transporters....Pages 471-491
Vitamin B12 Transporters....Pages 493-520
Back Matter....Pages 521-530
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