Ebook: Mechanisms and Mediators of Neuropathic Pain
- Tags: Immunology, Neurosciences, Pain Medicine, Life Sciences general
- Series: Progress in Inflammation Research
- Year: 2002
- Publisher: Birkhäuser Basel
- Edition: 1
- Language: English
- pdf
Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.
This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
Electrophysiological characteristics of injured peripheral nerves....Pages 3-22
Sodium channels and the molecular basis for pain....Pages 23-50
Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain....Pages 51-65
Neuroinflammation, cytokines and neuropathic pain....Pages 67-75
Front Matter....Pages 77-77
Pharmacological plasticity associated with neuropathic pain states....Pages 79-87
Sprouting and reorganization in the spinal cord after nerve injury....Pages 89-106
Front Matter....Pages 107-107
Pre-clinical nerve ligation models: behavior and electrophysiology....Pages 109-125
Animal models of toxic and metabolic sensory neuropathies....Pages 127-152
Role of adrenergic transmitters and receptors in nerve and tissue injury related pain....Pages 153-174
Evaluation of neuropathic pain....Pages 175-197
Front Matter....Pages 199-199
Glutamate receptor antagonists and neuropathic pain....Pages 201-209
Antiepileptic drugs for treatment of neuropathic pain....Pages 211-232
Calcium channel antagonists for the treatment of pain....Pages 233-243
Cholinergic, adenosinergic and a2 adrenergic mechanisms in chronic neuropathic pain....Pages 245-253
Back Matter....Pages 255-260
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
Electrophysiological characteristics of injured peripheral nerves....Pages 3-22
Sodium channels and the molecular basis for pain....Pages 23-50
Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain....Pages 51-65
Neuroinflammation, cytokines and neuropathic pain....Pages 67-75
Front Matter....Pages 77-77
Pharmacological plasticity associated with neuropathic pain states....Pages 79-87
Sprouting and reorganization in the spinal cord after nerve injury....Pages 89-106
Front Matter....Pages 107-107
Pre-clinical nerve ligation models: behavior and electrophysiology....Pages 109-125
Animal models of toxic and metabolic sensory neuropathies....Pages 127-152
Role of adrenergic transmitters and receptors in nerve and tissue injury related pain....Pages 153-174
Evaluation of neuropathic pain....Pages 175-197
Front Matter....Pages 199-199
Glutamate receptor antagonists and neuropathic pain....Pages 201-209
Antiepileptic drugs for treatment of neuropathic pain....Pages 211-232
Calcium channel antagonists for the treatment of pain....Pages 233-243
Cholinergic, adenosinergic and a2 adrenergic mechanisms in chronic neuropathic pain....Pages 245-253
Back Matter....Pages 255-260
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