Ebook: Animal Models — Disorders of Eating Behaviour and Body Composition

The book aims to review knowledge on the disorders of eating behaviour and body composition in some of the non-primate higher animals and to relate these to similar conditions in humans. With advances in understanding the nature of these disorders and their biological basis, it seems timely to assess what cross-species comparisons can tell us about the general underlying factors at work. This may also help to delineate what may be a general biological basis that humans share with their higher animal comrade species and what may distinguish human from non-human, particularly in a cultural context. This could help in combating better the problems of these conditions in the animal species as well as in man and in suggesting well-based preventive measures. As far as people are concerned the last two decades of the 20th century have shown a significant increase in obesity in the richer countries, particularly the USA (Table 1). Possibly associated with the obesity boom, there is an increasing awareness of other disorders of eating behaviour and body composition. These range from anorexia nervosa, at the other end of body composition to obesity, to others, such as bulimia, with more variable effects on body composition.

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This book deals with a novel aspect of a topical problem that is of widespread concern. Obesity and other eating disorders are significant human health problems that are proving highly resistant to prevention and cure. The recognition of important genotype/environment interaction in the causation of these problems and of the extensive genetic homology of higher animals justifies the importance of cross-species comparisons.
The book covers observations made on animals in the wild as well as experimental data on laboratory animals and farm animals in order to lay out the basic genetic and environmental factors underlying the control of appetite (including diet selection) and body weight. Breakdown in these intricate mechanisms are then compared to examine the possible common candidate genes and their interaction with non-genetic factors, particularly the availability of diet choice and of levels of body activity.
Animals have much to tell us about these mysteries and may significantly aid progress in dealing with what are still highly intractable and serious diseases of the modern world.

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This book deals with a novel aspect of a topical problem that is of widespread concern. Obesity and other eating disorders are significant human health problems that are proving highly resistant to prevention and cure. The recognition of important genotype/environment interaction in the causation of these problems and of the extensive genetic homology of higher animals justifies the importance of cross-species comparisons.
The book covers observations made on animals in the wild as well as experimental data on laboratory animals and farm animals in order to lay out the basic genetic and environmental factors underlying the control of appetite (including diet selection) and body weight. Breakdown in these intricate mechanisms are then compared to examine the possible common candidate genes and their interaction with non-genetic factors, particularly the availability of diet choice and of levels of body activity.
Animals have much to tell us about these mysteries and may significantly aid progress in dealing with what are still highly intractable and serious diseases of the modern world.
Content:
Front Matter....Pages i-ix
Front Matter....Pages xi-xi
Obesity Syndromes....Pages 1-18
The Spectrum of Eating Disorders in Humans....Pages 19-49
Free-Choice Diet Selection — The Economics of Eating....Pages 51-66
Front Matter....Pages 67-67
Diet Selection in Wild Animals....Pages 69-82
The Animal within: Lessons from the Feeding Behaviour of Farm Animals....Pages 83-96
Exercise and Diet-Induced Obesity in Mice....Pages 97-116
Front Matter....Pages 117-117
The Obesity (ob) Gene and Leptin in Animal Models of Obesity....Pages 119-131
Genetic Susceptibility of Rodents to Diet-Induced Obesity....Pages 133-155
Front Matter....Pages 157-157
Muscle Enhanced Traits in Cattle and Sheep....Pages 159-172
The Halothane Gene, Leanness and Stress Susceptibility in Pigs....Pages 173-190
Front Matter....Pages 191-191
The Anorexia Mouse....Pages 193-203
Anorexia-Like Wasting Syndromes in Pigs....Pages 205-221
Laboratory Animal Models for Investigating the Mechanisms and Function of Parasite-Induced Anorexia....Pages 223-241
Front Matter....Pages 243-243
Conclusion....Pages 245-246
Back Matter....Pages 247-251

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This book deals with a novel aspect of a topical problem that is of widespread concern. Obesity and other eating disorders are significant human health problems that are proving highly resistant to prevention and cure. The recognition of important genotype/environment interaction in the causation of these problems and of the extensive genetic homology of higher animals justifies the importance of cross-species comparisons.
The book covers observations made on animals in the wild as well as experimental data on laboratory animals and farm animals in order to lay out the basic genetic and environmental factors underlying the control of appetite (including diet selection) and body weight. Breakdown in these intricate mechanisms are then compared to examine the possible common candidate genes and their interaction with non-genetic factors, particularly the availability of diet choice and of levels of body activity.
Animals have much to tell us about these mysteries and may significantly aid progress in dealing with what are still highly intractable and serious diseases of the modern world.
Content:
Front Matter....Pages i-ix
Front Matter....Pages xi-xi
Obesity Syndromes....Pages 1-18
The Spectrum of Eating Disorders in Humans....Pages 19-49
Free-Choice Diet Selection — The Economics of Eating....Pages 51-66
Front Matter....Pages 67-67
Diet Selection in Wild Animals....Pages 69-82
The Animal within: Lessons from the Feeding Behaviour of Farm Animals....Pages 83-96
Exercise and Diet-Induced Obesity in Mice....Pages 97-116
Front Matter....Pages 117-117
The Obesity (ob) Gene and Leptin in Animal Models of Obesity....Pages 119-131
Genetic Susceptibility of Rodents to Diet-Induced Obesity....Pages 133-155
Front Matter....Pages 157-157
Muscle Enhanced Traits in Cattle and Sheep....Pages 159-172
The Halothane Gene, Leanness and Stress Susceptibility in Pigs....Pages 173-190
Front Matter....Pages 191-191
The Anorexia Mouse....Pages 193-203
Anorexia-Like Wasting Syndromes in Pigs....Pages 205-221
Laboratory Animal Models for Investigating the Mechanisms and Function of Parasite-Induced Anorexia....Pages 223-241
Front Matter....Pages 243-243
Conclusion....Pages 245-246
Back Matter....Pages 247-251
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