Ebook: Mammalian Carbohydrate Recognition Systems

In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins. This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins. These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In addition, several chapters are devoted to other major families of lectins that are found at the cell surface or in extracellular fluids which are involved in various recognition functions such as cell-cell interactions in inflammation and recognition of pathogen carbohydrates in host defence.

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In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins. This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins. These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In addition, several chapters are devoted to other major families of lectins that are found at the cell surface or in extracellular fluids which are involved in various recognition functions such as cell-cell interactions in inflammation and recognition of pathogen carbohydrates in host defence.

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In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins. This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins. These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In addition, several chapters are devoted to other major families of lectins that are found at the cell surface or in extracellular fluids which are involved in various recognition functions such as cell-cell interactions in inflammation and recognition of pathogen carbohydrates in host defence.
Content:
Front Matter....Pages I-XVII
Lectins of the ER Quality Control Machinery....Pages 1-17
MR60/ERGIC-53, a Mannose-Specific Shuttling Intracellular Membrane Lectin....Pages 19-38
The Cation-Dependent Mannose 6-Phosphate Receptor....Pages 39-56
Galectins Structure and Function — A Synopsis....Pages 57-83
Structure and Function of CD44: Characteristic Molecular Features and Analysis of the Hyaluronan Binding Site....Pages 85-103
Structure and Function of the Macrophage Mannose Receptor....Pages 105-121
The Man/GaINAc-4-SO4-Receptor has Multiple Specificities and Functions....Pages 123-138
Sialoadhesin Structure....Pages 139-151
Ligands for Siglecs....Pages 153-176
Functions of Selectins....Pages 177-200
Carbohydrate Ligands for the Leukocyte-Endothelium Adhesion Molecules, Selectins....Pages 201-223
Structures and Functions of Mammalian Collectins....Pages 225-248
Back Matter....Pages 249-252

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In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins. This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins. These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In addition, several chapters are devoted to other major families of lectins that are found at the cell surface or in extracellular fluids which are involved in various recognition functions such as cell-cell interactions in inflammation and recognition of pathogen carbohydrates in host defence.
Content:
Front Matter....Pages I-XVII
Lectins of the ER Quality Control Machinery....Pages 1-17
MR60/ERGIC-53, a Mannose-Specific Shuttling Intracellular Membrane Lectin....Pages 19-38
The Cation-Dependent Mannose 6-Phosphate Receptor....Pages 39-56
Galectins Structure and Function — A Synopsis....Pages 57-83
Structure and Function of CD44: Characteristic Molecular Features and Analysis of the Hyaluronan Binding Site....Pages 85-103
Structure and Function of the Macrophage Mannose Receptor....Pages 105-121
The Man/GaINAc-4-SO4-Receptor has Multiple Specificities and Functions....Pages 123-138
Sialoadhesin Structure....Pages 139-151
Ligands for Siglecs....Pages 153-176
Functions of Selectins....Pages 177-200
Carbohydrate Ligands for the Leukocyte-Endothelium Adhesion Molecules, Selectins....Pages 201-223
Structures and Functions of Mammalian Collectins....Pages 225-248
Back Matter....Pages 249-252
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