Ebook: Data Mining in Structural Biology: Signal Transduction and Beyond
- Tags: Biochemistry general, Cell Biology
- Series: Ernst Schering Research Foundation Workshop 34
- Year: 2001
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Structural biology is becoming a routine technique for structure de termination in pharmaceutical industries. The advances in molecular biology, crystal handling and data collection techniques, tunable syn chrotron radiation sources, and high-performance computing have all contributed to developments such as the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperature. The number of protein structures deposited in the Protein Databank has increased tremendously over the last 3-4 years. Since 1997, more than 1,500 structures have been deposited each year, and during the first 7 months of this year, 1,500 protein structures were already deposited. The numerous initiatives in the field of "structural genomics" distributed all over the world have led to the development of techniques for high-throughput structure determina tion, thereby contributing to the increase in the determination of three dimensional protein structures. This structural information is being ex plored in various ways in the drug discovery process. It is not only used in structure-based drug design of new low-molecular-weight li gands, but also in the early stages of target validation and assessment. With the number of protein sequences without significant homology to well-known proteins increasing, the technique of structure-sequence compatibility (threading) is increasingly used to assign a function to a given protein fold.
Content:
Front Matter....Pages I-XIII
Growth Factor Regulation of Kinases....Pages 1-18
Cell Cycle Regulation by Protein Kinases and Phosphatases....Pages 19-46
Structural Basis for Substrate Recognition and Control in Protein Kinases....Pages 47-69
The Selectivity of Small Molecules Towards Protein Tyrosine Kinases....Pages 71-80
Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C....Pages 81-99
The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genomics....Pages 101-121
Structure-Based Approaches in Modern Drug Discovery Research....Pages 123-142
DNA Recognition by NF?B and STAT Transcription Factors....Pages 143-166
Molecular Determinants for Agonist and Antagonist Binding to Steroid Nuclear Receptors....Pages 167-180
Estrogen Receptor-Cofactor Interactions as Targets for Novel Drug Discovery....Pages 181-201
Back Matter....Pages 203-209
Content:
Front Matter....Pages I-XIII
Growth Factor Regulation of Kinases....Pages 1-18
Cell Cycle Regulation by Protein Kinases and Phosphatases....Pages 19-46
Structural Basis for Substrate Recognition and Control in Protein Kinases....Pages 47-69
The Selectivity of Small Molecules Towards Protein Tyrosine Kinases....Pages 71-80
Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C....Pages 81-99
The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genomics....Pages 101-121
Structure-Based Approaches in Modern Drug Discovery Research....Pages 123-142
DNA Recognition by NF?B and STAT Transcription Factors....Pages 143-166
Molecular Determinants for Agonist and Antagonist Binding to Steroid Nuclear Receptors....Pages 167-180
Estrogen Receptor-Cofactor Interactions as Targets for Novel Drug Discovery....Pages 181-201
Back Matter....Pages 203-209
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