Ebook: Molecular Biology of Acute Lung Injury

Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.

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Content:
Front Matter....Pages i-xiii
Signal Transduction Pathways in Acute Lung Injury: Nf-?B and Ap-1....Pages 1-16
Innate Immune Mechanisms Triggering Lung Injury....Pages 17-33
The Role of Chemokines in the Recruitment of Leukocytes During Lung Inflammation....Pages 35-51
Regulation of Lung Immunity: Significance of the Cytokine Environment....Pages 53-69
Role of Complement in Acute Lung Injury....Pages 71-81
Oxidant Stress in Acute Lung Injury....Pages 83-99
Endogenous Nitric Oxide in Acute Lung Injury....Pages 101-117
Heme Oxygenase-1 in Acute Lung Injury....Pages 119-132
Pulmonary Endothelial Surface Redox Activity: Roles in Propagation of and Protection from Injury....Pages 133-148
Mechanisms of Lung Epithelial Cell Injury by Pseudomonas Aeruginosa ....Pages 149-161
Alveolar Epithelial Repair in Acute Lung Injury....Pages 163-176
Molecular Basis for Surfactant Function in ARDS....Pages 177-191
Pulmonary Collectins and Defensins....Pages 193-211
Lung Repair, Remodeling, and Fibrosis....Pages 213-227
Apoptosis in Acute Lung Injury....Pages 229-244
Corticosteroid Treatment in Unresolving ARDS....Pages 245-256
Anti-Inflammatory Cytokines: Role in Regulation of Acute Lung Injury....Pages 257-273
The Heat Shock Response and Heat Shock Protein 70: Cytoprotection in Acute Lung Injury....Pages 275-288
Biotrauma: Signal Transduction and Gene Expression in the Lung....Pages 289-325
Back Matter....Pages 327-329

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Content:
Front Matter....Pages i-xiii
Signal Transduction Pathways in Acute Lung Injury: Nf-?B and Ap-1....Pages 1-16
Innate Immune Mechanisms Triggering Lung Injury....Pages 17-33
The Role of Chemokines in the Recruitment of Leukocytes During Lung Inflammation....Pages 35-51
Regulation of Lung Immunity: Significance of the Cytokine Environment....Pages 53-69
Role of Complement in Acute Lung Injury....Pages 71-81
Oxidant Stress in Acute Lung Injury....Pages 83-99
Endogenous Nitric Oxide in Acute Lung Injury....Pages 101-117
Heme Oxygenase-1 in Acute Lung Injury....Pages 119-132
Pulmonary Endothelial Surface Redox Activity: Roles in Propagation of and Protection from Injury....Pages 133-148
Mechanisms of Lung Epithelial Cell Injury by Pseudomonas Aeruginosa ....Pages 149-161
Alveolar Epithelial Repair in Acute Lung Injury....Pages 163-176
Molecular Basis for Surfactant Function in ARDS....Pages 177-191
Pulmonary Collectins and Defensins....Pages 193-211
Lung Repair, Remodeling, and Fibrosis....Pages 213-227
Apoptosis in Acute Lung Injury....Pages 229-244
Corticosteroid Treatment in Unresolving ARDS....Pages 245-256
Anti-Inflammatory Cytokines: Role in Regulation of Acute Lung Injury....Pages 257-273
The Heat Shock Response and Heat Shock Protein 70: Cytoprotection in Acute Lung Injury....Pages 275-288
Biotrauma: Signal Transduction and Gene Expression in the Lung....Pages 289-325
Back Matter....Pages 327-329
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