Ebook: Purinergic and Pyrimidinergic Signalling I: Molecular, Nervous and Urogenitary System Function

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

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Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

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Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Content:
Front Matter....Pages I-XXX
Purinergic Neurotransmission: An Historical Background....Pages 1-16
Front Matter....Pages 17-17
P1 Receptors....Pages 19-45
P2X Receptors....Pages 47-63
P2Y Receptors: Structure and Function....Pages 65-88
Purinergic Signalling in Development....Pages 89-127
P1 and P2 Purine and Pyrimidine Receptor Ligands....Pages 129-175
Front Matter....Pages 177-177
Regulation of Purine Release....Pages 179-208
Ecto-Nucleotidases....Pages 209-250
Role of Purines and Pyrimidines in the Central Nervous System....Pages 251-288
The Role of Purines in the Peripheral Nervous System....Pages 289-304
Trophic Roles of Purines and Pyrimidines....Pages 305-338
Nucleoside and Nucleotide Transmission in Sensory Systems....Pages 339-369
Roles of Purines in Nociception and Pain....Pages 371-401
Uridine and Pyrimidine Nucleotides in Cell Function....Pages 403-421
Purinergic Signalling in Lower Urinary Tract....Pages 423-515
Back Matter....Pages 517-526

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Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Content:
Front Matter....Pages I-XXX
Purinergic Neurotransmission: An Historical Background....Pages 1-16
Front Matter....Pages 17-17
P1 Receptors....Pages 19-45
P2X Receptors....Pages 47-63
P2Y Receptors: Structure and Function....Pages 65-88
Purinergic Signalling in Development....Pages 89-127
P1 and P2 Purine and Pyrimidine Receptor Ligands....Pages 129-175
Front Matter....Pages 177-177
Regulation of Purine Release....Pages 179-208
Ecto-Nucleotidases....Pages 209-250
Role of Purines and Pyrimidines in the Central Nervous System....Pages 251-288
The Role of Purines in the Peripheral Nervous System....Pages 289-304
Trophic Roles of Purines and Pyrimidines....Pages 305-338
Nucleoside and Nucleotide Transmission in Sensory Systems....Pages 339-369
Roles of Purines in Nociception and Pain....Pages 371-401
Uridine and Pyrimidine Nucleotides in Cell Function....Pages 403-421
Purinergic Signalling in Lower Urinary Tract....Pages 423-515
Back Matter....Pages 517-526
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