Ebook: Phylogenetic Perspectives on the Vertebrate Immune System

This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.

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This volume describes the evolution of immune systems and covers new molecular information concerning the development of recognition, immunoglobulins, and cytokines. Invertebrates and lower vertebrates contribute to a more complete understanding and clarification of the immune/inflammatory response in higher animals. Chapters detail the major areas of immunology and encourage a more extensive development of invertebrate models as useful and unique in modern immunological and industrial laboratories. In addition, chapters focus on mechanisms of development and immunodefenses in protostome and deuterostome and lower vertebrates. There is a strong emphasis on evolutionary cell biology, phylogenetic inferences, and the evolution of recognition and regulatory systems.

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This volume describes the evolution of immune systems and covers new molecular information concerning the development of recognition, immunoglobulins, and cytokines. Invertebrates and lower vertebrates contribute to a more complete understanding and clarification of the immune/inflammatory response in higher animals. Chapters detail the major areas of immunology and encourage a more extensive development of invertebrate models as useful and unique in modern immunological and industrial laboratories. In addition, chapters focus on mechanisms of development and immunodefenses in protostome and deuterostome and lower vertebrates. There is a strong emphasis on evolutionary cell biology, phylogenetic inferences, and the evolution of recognition and regulatory systems.
Content:
Front Matter....Pages i-xii
New Major Histocompatibility Complex Class IIB Genes From Nurse Shark....Pages 1-11
Evolutionary Factors in the Emergence of the Combinatorial Germline Antibody Repertoire....Pages 13-30
Molecular Characterization of IL-1-Like Molecules From Lower Vertebrates and Invertebrates....Pages 31-40
Phylogeny of Vertebrate Cytokines....Pages 41-54
Antimicrobial Proteins in Crustaceans....Pages 55-62
Form, Function and Phylogenetic Relationships of Mosquito Immune Peptides....Pages 63-69
Reactive Oxygen Species and Antimicrobial Defenses of Invertebrates: A Bivalve Model....Pages 71-76
A Role For Protease Inhibitors in Immunity of Long-Lived Animals....Pages 77-87
Annelid Humoral Immunity: Cell Lysis in Earthworms....Pages 89-94
Horseshoe Crab Hemocyte- Derived Lectin Recognizing Specific 0-Antigens of Lipopolysaccharides....Pages 95-112
Hemolytic Capacity, Properties, and Activation Requirements of Cobra Venom Factor-Treated Chicken Serum....Pages 113-129
Molecular Studies of the Molluscan Response to Digenean Infection....Pages 131-139
Insect Lectins and Innate Immunity....Pages 141-160
Collagenous Lectins in Tunicates and the Proteolytic Activation of Complement....Pages 161-167
Immunological Properties of Heat Shock Proteins are Phylogenetically Conserved....Pages 169-183
Eicosanoids in Insect Immune Signal Transduction....Pages 185-190
Lectins From Tunicates: Structure-Function Relationships in Innate Immunity....Pages 191-194
Control Mechanisms of the Prophenoloxidase Cascade....Pages 195-202
Activated Prophenoloxidase Engaged in the Cell Clump/Cell Adhesion of Coleopteran Insect, Tenebrio Molitor Larvae....Pages 203-207
Three Kinds of Encapsulation-Relating Factors in Coleopteran Insect, Tenebrio Molitor Larvae....Pages 209-222
Proteolytic Activation of Prophenoloxidase in an Insect Manduca Sexta....Pages 223-228
Hemolymph Proteinases in Immune Responses of Manduca sexta....Pages 229-236
Cytotoxic Reactions Associated with Insect Immunity....Pages 237-249
The Complement System in Sea Urchins....Pages 251-263
Back Matter....Pages 265-273
....Pages 275-287