Ebook: Signaling Pathways for Translation: Stress, Calcium, and Rapamycin

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

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This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

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This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.
Content:
Front Matter....Pages I-X
The Regulation of eIF4F During Cell Growth and Cell Death....Pages 1-37
Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells....Pages 39-56
Initiation Factor eIF2? Phosphorylation in Stress Responses and Apoptosis....Pages 57-89
Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium....Pages 91-129
Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation....Pages 131-142
Control of Translation by the Target of Rapamycin Proteins....Pages 143-174
Back Matter....Pages 175-176

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This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.
Content:
Front Matter....Pages I-X
The Regulation of eIF4F During Cell Growth and Cell Death....Pages 1-37
Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells....Pages 39-56
Initiation Factor eIF2? Phosphorylation in Stress Responses and Apoptosis....Pages 57-89
Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium....Pages 91-129
Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation....Pages 131-142
Control of Translation by the Target of Rapamycin Proteins....Pages 143-174
Back Matter....Pages 175-176
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