Ebook: Prolactin

It is an authentic privilege to have the opportunity to assemble and edit a new volume on "Prolactin," the first in several decades to be devoted to this fascinating hormone in all its aspects. The obvious clinical rationale for understanding prolactin (PRL) is the frequent occurrence of prolactinomas, the most common type of pituitary tumor. Fortunately, medical management of prolactinomas can be based on our under­ standing of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for proiactinomas are highly successful and well tolerated. Be­ cause of the historical and practical importance of knowledge regarding the hypothala­ mus-Iactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these. PRL is the primary hormone that is responsible for "parental care" in many verte­ brate species. This reproductive strategy is not unique to mammals, but it has devel­ oped through evolution to be the central distinguishing feature of the mammalian life cycle. Among the mammals, mice have become the most effective research species in recent years. This can be traced to the development of a wide range of methods for manipulating mouse genetics, and thereby influencing development, physiology and behavior. Mice also provide a profound illustration of the physiological challenges faced in maternity. Female mice undergo a post-partum estrous, and often are both pregnant and lactating simultaneously.

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This is the first volume in several decades to be devoted to all the aspects of Prolactin.
Medical management of prolactinomas can be based on our understanding of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for prolactinomas are highly successful and well tolerated. Because of the historical and practical importance of knowledge regarding the hypothalamus-lactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these.
Our understanding of the roles of PRL in the integration of maternal physiology is still very incomplete. The merger of genetics, developmental biology, and physiology has offered new avenues to study these essential functions. Several chapters in the text review our current understandings of behavioral, reproductive, metabolic and developmental functions of PRL that relate to maternal care. The fundamental PRL signaling pathways, including relevant kinases, transcription factors, and comodulatory protein findings are reviewed from the receptor level to the nucleus.
Prolactin gives a complete state-of-the-art review on Prolactin by the authorities.

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This is the first volume in several decades to be devoted to all the aspects of Prolactin.
Medical management of prolactinomas can be based on our understanding of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for prolactinomas are highly successful and well tolerated. Because of the historical and practical importance of knowledge regarding the hypothalamus-lactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these.
Our understanding of the roles of PRL in the integration of maternal physiology is still very incomplete. The merger of genetics, developmental biology, and physiology has offered new avenues to study these essential functions. Several chapters in the text review our current understandings of behavioral, reproductive, metabolic and developmental functions of PRL that relate to maternal care. The fundamental PRL signaling pathways, including relevant kinases, transcription factors, and comodulatory protein findings are reviewed from the receptor level to the nucleus.
Prolactin gives a complete state-of-the-art review on Prolactin by the authorities.
Content:
Front Matter....Pages i-vii
Hypothalamic Control of Prolactin Synthesis and Secretion....Pages 1-24
Role of Prolactin in Developmental Differentiation of Hypothalamic Dopaminergic Neurons....Pages 25-43
Mechanisms of Dopamine Action on the Lactotroph....Pages 45-61
Regulation of Lactotrophs and Prolactin Secretion in Non-mammalian Vertebrates....Pages 63-79
Prolactinomas....Pages 81-99
The Psychosomatic Interface: Hyperprolactinemia....Pages 101-117
Genetics of Prolactinomas....Pages 119-137
Rodent Prolactin Family and Pregnancy....Pages 139-167
Human Uteroplacental Lactogens: Physiology and Molecular Biology....Pages 169-187
Structure-Function Relationships in Prolactin....Pages 189-217
Mammary Gland Development....Pages 219-232
Actions of Prolactin in the Prostate Gland....Pages 233-245
Prolactin Regulation of Cell Proliferation and Apoptosis....Pages 247-264
Mechanisms of Luteal Cell Regulation by Prolactin....Pages 265-295
Regulation of Pancreatic Islets by Prolactin, Growth Hormone and Placental Lactogen....Pages 297-316
In Vitro Effects of Prolactin on the Lympho-Hemopoietic System....Pages 317-339
Prolactin Receptors....Pages 341-353
Prolactin Receptor Signal Transduction....Pages 355-379
Transcription Factors, Cofactors and Target Genes Mediating Prolactin Signals....Pages 381-404
Back Matter....Pages 405-412

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This is the first volume in several decades to be devoted to all the aspects of Prolactin.
Medical management of prolactinomas can be based on our understanding of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for prolactinomas are highly successful and well tolerated. Because of the historical and practical importance of knowledge regarding the hypothalamus-lactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these.
Our understanding of the roles of PRL in the integration of maternal physiology is still very incomplete. The merger of genetics, developmental biology, and physiology has offered new avenues to study these essential functions. Several chapters in the text review our current understandings of behavioral, reproductive, metabolic and developmental functions of PRL that relate to maternal care. The fundamental PRL signaling pathways, including relevant kinases, transcription factors, and comodulatory protein findings are reviewed from the receptor level to the nucleus.
Prolactin gives a complete state-of-the-art review on Prolactin by the authorities.
Content:
Front Matter....Pages i-vii
Hypothalamic Control of Prolactin Synthesis and Secretion....Pages 1-24
Role of Prolactin in Developmental Differentiation of Hypothalamic Dopaminergic Neurons....Pages 25-43
Mechanisms of Dopamine Action on the Lactotroph....Pages 45-61
Regulation of Lactotrophs and Prolactin Secretion in Non-mammalian Vertebrates....Pages 63-79
Prolactinomas....Pages 81-99
The Psychosomatic Interface: Hyperprolactinemia....Pages 101-117
Genetics of Prolactinomas....Pages 119-137
Rodent Prolactin Family and Pregnancy....Pages 139-167
Human Uteroplacental Lactogens: Physiology and Molecular Biology....Pages 169-187
Structure-Function Relationships in Prolactin....Pages 189-217
Mammary Gland Development....Pages 219-232
Actions of Prolactin in the Prostate Gland....Pages 233-245
Prolactin Regulation of Cell Proliferation and Apoptosis....Pages 247-264
Mechanisms of Luteal Cell Regulation by Prolactin....Pages 265-295
Regulation of Pancreatic Islets by Prolactin, Growth Hormone and Placental Lactogen....Pages 297-316
In Vitro Effects of Prolactin on the Lympho-Hemopoietic System....Pages 317-339
Prolactin Receptors....Pages 341-353
Prolactin Receptor Signal Transduction....Pages 355-379
Transcription Factors, Cofactors and Target Genes Mediating Prolactin Signals....Pages 381-404
Back Matter....Pages 405-412
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