Ebook: Purinergic and Pyrimidinergic Signalling II: Cardiovascular, Respiratory, Immune, Metabolic and Gastrointestinal Tract Function
- Tags: Pharmacology/Toxicology, Human Physiology, Immunology, Endocrinology, Cell Biology, Molecular Medicine
- Series: Handbook of Experimental Pharmacology 151 / 2
- Year: 2001
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Content:
Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
P1 Receptors in the Cardiovascular System....Pages 3-32
P1 and P2 Receptors in the Renal System....Pages 33-71
P2 Receptors in the Cardiovascular System....Pages 73-99
Roles of Purines and Pyrimidines in Endothelium....Pages 101-120
P1 and P2 Receptors in Platelets....Pages 121-139
Purinergic Signalling in Gut....Pages 141-238
P1 Receptors in the Respiratory System....Pages 239-279
P2 Receptors in the Respiratory System....Pages 281-300
Front Matter....Pages 301-301
Role of P1 Receptors in Inflammation....Pages 303-321
Role of P2 Receptors in the Immune System....Pages 323-354
On the Role of the P2X7 Receptor in the Immune System....Pages 355-374
Purinergic Receptors and the Pharmacology of Type 2 Diabetes....Pages 377-391
Purinergic and Pyrimidinergic Receptor Signaling in Bone Cells....Pages 393-406
Clinical Opportunities in Purinergic Neuromodulation....Pages 407-434
Back Matter....Pages 435-442
Content:
Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
P1 Receptors in the Cardiovascular System....Pages 3-32
P1 and P2 Receptors in the Renal System....Pages 33-71
P2 Receptors in the Cardiovascular System....Pages 73-99
Roles of Purines and Pyrimidines in Endothelium....Pages 101-120
P1 and P2 Receptors in Platelets....Pages 121-139
Purinergic Signalling in Gut....Pages 141-238
P1 Receptors in the Respiratory System....Pages 239-279
P2 Receptors in the Respiratory System....Pages 281-300
Front Matter....Pages 301-301
Role of P1 Receptors in Inflammation....Pages 303-321
Role of P2 Receptors in the Immune System....Pages 323-354
On the Role of the P2X7 Receptor in the Immune System....Pages 355-374
Purinergic Receptors and the Pharmacology of Type 2 Diabetes....Pages 377-391
Purinergic and Pyrimidinergic Receptor Signaling in Bone Cells....Pages 393-406
Clinical Opportunities in Purinergic Neuromodulation....Pages 407-434
Back Matter....Pages 435-442
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