Ebook: Signaling Pathways for Translation: Insulin and Nutrients

This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.

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This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.

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This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.
Content:
Front Matter....Pages I-X
Insulin Signaling and the Control of PHAS-I Phosphorylation....Pages 1-31
Insulin, Phorbol Ester and Serum Regulate the Elongation Phase of Protein Synthesis....Pages 33-48
Regulation of Protein Synthesis by Insulin Through IRS-1....Pages 49-93
Regulation of Eukaryotic Initiation Factor eIF2B....Pages 95-114
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity....Pages 115-154
Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells....Pages 155-184
Back Matter....Pages 185-186

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This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.
Content:
Front Matter....Pages I-X
Insulin Signaling and the Control of PHAS-I Phosphorylation....Pages 1-31
Insulin, Phorbol Ester and Serum Regulate the Elongation Phase of Protein Synthesis....Pages 33-48
Regulation of Protein Synthesis by Insulin Through IRS-1....Pages 49-93
Regulation of Eukaryotic Initiation Factor eIF2B....Pages 95-114
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity....Pages 115-154
Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells....Pages 155-184
Back Matter....Pages 185-186
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