Ebook: The Small GTPase Ran

The Ras-related nuclear protein Ran is a member of the so-called Ras-superfamily of small GTP-binding proteins and hydrolyzing proteins. A variety of edited anthologies related to the Ras-superfamily have appeared over the last decade, but Ran has been under-represented in all of them. This under-representation is not due to the fact that Ran is unimportant or non-abundant. It is almost certainly because Ran was discovered and its functions elucidated only recently, and that some of these functions may not follow the typical Ras-superfamily paradign.
Even workers in the field have difficulty keeping up with the Ran literature, and most outsiders rarely try even though they may be aware that major breakthroughs regarding the mechanisms of nuclear-cytosolic transport, mitosis and the maintenance of nuclear structure have depended upon an understanding of Ran function. TheSmall GTPase Ran is meant to provide specialists with a concise summary of some of the recent research in this area, along with background describing its initial identification and early characterization.

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Content:
Front Matter....Pages i-xxiii
The Role of Ran in Nuclear Import....Pages 1-13
Ran GTPASE Regulation of the CRM1-Dependent Export Pathway....Pages 15-31
Role of Ran GTPase in RNA Processing and Export of RNA from the Nucleus to the Cytosol: Insights from Budding Yeast....Pages 33-58
Direct and Indirect Roles of Ran-GTP in Nuclear Export of RNAS in Higher Eukaryotes....Pages 59-83
The Role of Ran in Regulating Microtubule Spindle Assembly....Pages 85-104
Multiple Roles of the Ran GTPase During the Cell Cycle....Pages 105-122
The Multiple Roles of Ran in the Fission Yeast Schizosaccharomyces Pombe ....Pages 123-144
Mitotic Control by Ran and RanBP1 in Mammalian Cells....Pages 145-162
Ran Regulation by Ran GEF and Ran GAP....Pages 163-176
Structural Views of the Ran GTPase Cycle....Pages 177-201
Back Matter....Pages 203-214

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Content:
Front Matter....Pages i-xxiii
The Role of Ran in Nuclear Import....Pages 1-13
Ran GTPASE Regulation of the CRM1-Dependent Export Pathway....Pages 15-31
Role of Ran GTPase in RNA Processing and Export of RNA from the Nucleus to the Cytosol: Insights from Budding Yeast....Pages 33-58
Direct and Indirect Roles of Ran-GTP in Nuclear Export of RNAS in Higher Eukaryotes....Pages 59-83
The Role of Ran in Regulating Microtubule Spindle Assembly....Pages 85-104
Multiple Roles of the Ran GTPase During the Cell Cycle....Pages 105-122
The Multiple Roles of Ran in the Fission Yeast Schizosaccharomyces Pombe ....Pages 123-144
Mitotic Control by Ran and RanBP1 in Mammalian Cells....Pages 145-162
Ran Regulation by Ran GEF and Ran GAP....Pages 163-176
Structural Views of the Ran GTPase Cycle....Pages 177-201
Back Matter....Pages 203-214
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