Ebook: Advances in Eicosanoid Research
- Tags: Biotechnology, Immunology, Biochemistry general
- Series: Ernst Schering Research Foundation Workshop 31
- Year: 2000
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.
Content:
Front Matter....Pages I-XII
The Mechanism of Action of Anti-Inflammatory Drugs....Pages 1-23
Human Group-V Phospholipase-A2 Expression in Pichia pastoris and Its Role in Eicosanoid Generation....Pages 25-52
Fatty-Acid Substrate Interactions with Cyclo-oxygenases....Pages 53-64
Structure, Function and Inhibition of Cyclo-oxygenases....Pages 65-83
Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis....Pages 85-96
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice....Pages 97-124
Leukotriene-B4 Receptor and Signal Transduction....Pages 125-141
Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: A Window for Therapeutic Opportunity....Pages 143-185
Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation....Pages 187-199
The Role of Eicosanoids in Tumor Growth and Metastasis....Pages 201-217
Back Matter....Pages 219-225
Content:
Front Matter....Pages I-XII
The Mechanism of Action of Anti-Inflammatory Drugs....Pages 1-23
Human Group-V Phospholipase-A2 Expression in Pichia pastoris and Its Role in Eicosanoid Generation....Pages 25-52
Fatty-Acid Substrate Interactions with Cyclo-oxygenases....Pages 53-64
Structure, Function and Inhibition of Cyclo-oxygenases....Pages 65-83
Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis....Pages 85-96
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice....Pages 97-124
Leukotriene-B4 Receptor and Signal Transduction....Pages 125-141
Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: A Window for Therapeutic Opportunity....Pages 143-185
Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation....Pages 187-199
The Role of Eicosanoids in Tumor Growth and Metastasis....Pages 201-217
Back Matter....Pages 219-225
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