Ebook: The Hepatitis C Viruses

Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.

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Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.

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Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
Content:
Front Matter....Pages I-IX
Studies of Non-A, Non-B Hepatitis and Characterization of the Hepatitis C Virus in Chimpanzees....Pages 1-23
Hepatitis C Epidemiology....Pages 25-41
Natural History and Disease Manifestations of Hepatitis C Infection....Pages 43-54
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties....Pages 55-84
Internal Ribosome Entry Site-Mediated Translation in Hepatitis C Virus Replication....Pages 85-116
Hepatitis C Virus Core Protein: Possible Roles in Viral Pathogenesis....Pages 117-134
Folding, Assembly and Subcellular Localization of Hepatitis C Virus Glycoproteins....Pages 135-148
Structure and Function of the Hepatitis C Virus NS3-NS4A Serine Proteinase....Pages 149-169
Structure and Function of Hepatitis C Virus NS3 Helicase....Pages 171-196
Evading the Interferon Response: Hepatitis C Virus and the Interferon-Induced Protein Kinase, PKR....Pages 197-224
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)....Pages 225-260
Systems to Culture Hepatitis C Virus....Pages 261-278
Characterization of Hepatitis C Virus Infectious Clones in Chimpanzees: Long-Term Studies....Pages 279-298
Cell Mediated Immune Response to the Hepatitis C Virus....Pages 299-325
Strategies and Prospects for Vaccination Against the Hepatitis C Viruses....Pages 327-339
The GB Agent....Pages 341-375
Back Matter....Pages 377-384

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Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
Content:
Front Matter....Pages I-IX
Studies of Non-A, Non-B Hepatitis and Characterization of the Hepatitis C Virus in Chimpanzees....Pages 1-23
Hepatitis C Epidemiology....Pages 25-41
Natural History and Disease Manifestations of Hepatitis C Infection....Pages 43-54
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties....Pages 55-84
Internal Ribosome Entry Site-Mediated Translation in Hepatitis C Virus Replication....Pages 85-116
Hepatitis C Virus Core Protein: Possible Roles in Viral Pathogenesis....Pages 117-134
Folding, Assembly and Subcellular Localization of Hepatitis C Virus Glycoproteins....Pages 135-148
Structure and Function of the Hepatitis C Virus NS3-NS4A Serine Proteinase....Pages 149-169
Structure and Function of Hepatitis C Virus NS3 Helicase....Pages 171-196
Evading the Interferon Response: Hepatitis C Virus and the Interferon-Induced Protein Kinase, PKR....Pages 197-224
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)....Pages 225-260
Systems to Culture Hepatitis C Virus....Pages 261-278
Characterization of Hepatitis C Virus Infectious Clones in Chimpanzees: Long-Term Studies....Pages 279-298
Cell Mediated Immune Response to the Hepatitis C Virus....Pages 299-325
Strategies and Prospects for Vaccination Against the Hepatitis C Viruses....Pages 327-339
The GB Agent....Pages 341-375
Back Matter....Pages 377-384
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