Ebook: Metallothionein IV

The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

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The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

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The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.
Content:
Front Matter....Pages I-XLVI
Front Matter....Pages 1-1
Nomenclature of metallothionein: Proposal for a revision....Pages 3-6
Metallothionein: Molecular evolution and classification....Pages 7-13
Structural and biological studies on native bovine Cu,Zn-metallothionein-3....Pages 15-21
Circular dichroism, emission, and exafs studies of Ag(I), Cd(II), Cu(I), and Hg(II) binding to metallothioneins and modeling the metal binding site....Pages 23-35
Metallothionein structure update....Pages 37-43
Simulation of Zn/Cd binding in mammalian metallothionein domains....Pages 45-49
The growth inhibitory activity of metallothionein-3 correlates with its novel ? domain sequence rather than metal binding properties....Pages 51-54
Recombinant synthesis and metal-binding abilities of mouse metallothionein 1 and its ?- and ?-domains....Pages 55-61
Biochemical characterization of monomeric and dimeric cadmium-substituted metallothionein-3....Pages 63-69
Front Matter....Pages 71-71
Mammalian metallothionein sub-isoform separation by RP-HPLC with online UV and electrochemical detection....Pages 73-84
Characterisation of mammalian Cd, Zn metallothioneins using differential pulse polarography....Pages 85-91
Comparison of CZE and MECC separations of MT isoforms....Pages 93-97
Synthetic peptides and domains of metallothionein for structure function studies: rabbit liver peptide MT-IIA 49–61 and lobster MT ?N ?C and ?C>N domains....Pages 99-109
Characterization of isometallothioneins in Chang liver cells and the transient accumulation of metallothionein and glutathione during cell proliferation....Pages 111-115
Quantification of cytosolic metallothionein contents by a developed assay system using immobilized antibody....Pages 117-123
Protein engineering of metallothionein to study the metal-binding ability....Pages 125-128
Metal binding proteins: Molecular engineering of improvements in metal specificity....Pages 129-136
Molecular splicing of metallothionein — study on domains of metallothionein....Pages 137-143
Front Matter....Pages 145-153
Involvement of metallothionein in female squirrelfish reproduction....Pages 155-155
Front Matter....Pages 157-165
Accumulation of untranslated metallothionein mRNA in antarctic hemoglobinless fish (icefish)....Pages 155-155
Structure and function of metallothionein isoforms in terrestrial snails....Pages 167-172
Functional and regulatory aspects of teleost metallothionein....Pages 173-178
Metallothionein induction in mussels exposed to a metal mixture....Pages 179-185
Synthesis and properties of class III metallothioneins of Schizosaccharomyces pombe in response to cadmium and zinc....Pages 187-194
Phytochelatins (class III metallothioneins) and their desglycyl peptides induced by cadmium in root cultures of Rubia tinctorum L.....Pages 195-199
Front Matter....Pages 201-205
Metallothionein facts and frustrations....Pages 207-212
Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1....Pages 213-213
New insights into the mechanisms of cadmium regulation of mouse metallothionein-I gene expression....Pages 215-221
Activation of mouse metallothionein I promoter by cadmium in human neuroblastoma cells....Pages 223-226
Transcription factors involved in heavy metal regulation of the human metallothionein-IIA gene....Pages 227-232
Transcriptional regulation of the gene encoding mouse metallothionein-3 and its expression in the organs of the reproductive system....Pages 233-236
Dynamic regulation of yeast metallothionein gene transcription via metalloregulatory signaling factors....Pages 237-241
Metal regulation of mammalian metal responsive element (MRE) binding proteins....Pages 243-249
Metallothionein and hormone responsiveness....Pages 251-252
Synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid....Pages 253-259
Hammerhead ribozymes mediated down-regulation of rat metallothionein mrnas expression....Pages 261-266
Inactivation of metal-induced metallothionein gene expression by protein kinase C inhibitor....Pages 267-272
Cadmium-induced metallothionein expression and metallothionein mRNA in mice....Pages 273-280
Front Matter....Pages 281-285
The nuclear-cytoplasmic presence of metallothionein in cells during differentiation and development....Pages 287-288
Metallothionein and male genital organs....Pages 289-289
Induction of metallothionein-like cadmium binding protein in testis and its protective role against cadmium toxicity....Pages 291-294
Zinc homeostasis during pregnancy in metallothionein-null mice on a low zinc diet....Pages 295-300
Restriction of cadmium transfer to egg from laying hen exposed to cadmium: Involvement of metallothionein in the ovaries....Pages 301-307
Metallothionein expression during wool follicle development in foetal sheep....Pages 309-313
A role of hepatic metallothionein on mercury distribution in fetal guinea pigs after in utero exposure to mercury vapor....Pages 315-320
Cell differentiation alters metallothionein expression in avian growth plate chondrocytes....Pages 321-324
Front Matter....Pages 325-331
Metallothionein in oxidative stress of Parkinson’s disease....Pages 333-338
Metallothionein-1,2 and heme oxygenase-1 are expressed in damaged brain regions following chemically-induced seizures....Pages 339-339
Molecular cloning and expression of the metallothionein (MT)-I and MT-III in brain lesions of dogs....Pages 341-349
Liver and brain metallothionein regulation in transgenic mice overexpressing interleukin-6 and in mice carrying a null mutation in the interleukin-6 gene....Pages 351-357
Effects of capsaicin on metallothionein (MT) mRNA in sensory neurons: Possible role of MT-III in nociception....Pages 359-362
Metallothionein expression in the mammalian brain....Pages 363-370
Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity....Pages 371-376
Metallothionein in the cerebral cortex of rats showing hereditary high ability in sidman avoidance test....Pages 377-382
Front Matter....Pages 383-387
Roles of metallothionein in the cytotoxicity of copper in the liver of LEC rats....Pages 389-394
Fate of copper and metallothionein in the liver of LEC rats....Pages 395-395
Relationship between Cu metabolism hereditary disorders and distribution of Cu-metallothionein in kidneys....Pages 397-402
Zincsulphate protects from streptozotocin-induced diabetes mellitus in mice: A function of metallothionein?....Pages 403-412
Front Matter....Pages 413-419
MT does not protect endocrine cell damage induced by alloxan in pancreas of mice....Pages 421-428
Plasma MT levels in diabetic and renal failure patients....Pages 395-395
Metallothionein-mediated alterations in autoimmune disease processes....Pages 429-431
Dietary zinc, photoimmunosuppression and metallothionein (MT)....Pages 433-435
Front Matter....Pages 437-444
Metallothionein-null mice are susceptible to chronic CdCl2-induced nephropathy: Cd-induced renal injury is not necessarily mediated by CdMT....Pages 445-449
Cellular metallothionein: Properties of apometallothionein and the comparative toxicity of Cd2+ and Cd-metallothionein....Pages 451-451
Zinc-induced protection against cadmium-metallothionein nephrotoxicity depends on glutathione status....Pages 453-457
Mechanism of improved cadmium-induced renal dysfunction after cessation of cadmium exposure....Pages 459-466
The role of metallothionein in cadmium-induced bone resorption....Pages 467-469
Metallothionein induction in human proximal tubular cell cultures — lack of protection against heavy metal toxicity....Pages 471-472
Relationship of metallothionein to cadmium and to zinc in human liver and kidney....Pages 473-476
Apoptosis of human kidney 293 cells is promoted by polymerized Cd-metallothionein....Pages 477-484
Front Matter....Pages 485-488
Subcellular localization mediated functioning of metallothionein: Protection against oxygen radicals and anticancer agents....Pages 489-495
Obesity and hyperleptinemia in a colony of metallothionein (-I and -II) null mice....Pages 497-497
Cardiac protection by metallothionein against ischemia-reperfusion injury and its possible relation to ischemic preconditioning....Pages 499-503
Metallothionein and its importance relative to glutathione in cardiac protection against doxorubicin toxicity....Pages 505-510
Metallothionein metal composition is a determinant of its induction of the mitochondrial permeability transition....Pages 511-516
Protective effect of metallothionein on DNA damage induced by hydrogen peroxide and ferric ion-nitrilotriacetic acid....Pages 517-522
Effect of metallothionein on cardiac reperfusion injury in rats....Pages 523-527
Susceptibility to metals and radical-inducing chemicals of metallothioneinnull mice....Pages 529-534
Front Matter....Pages 535-539
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity....Pages 541-546
Effect of oxidative stress and bioavailable zinc on metallothionein in cultured human retinal pigment epithelial cells (RPE)....Pages 497-497
Specific binding sites of metallothionein on endothelium of small vessels in myocardium....Pages 547-552
Front Matter....Pages 553-559
Further studies on the role of metallothionein in the antitumor effects of cadmium....Pages 561-566
Effects of metallothionein expression on development of drug resistance....Pages 567-567
A chemical mechanism for inactivation of anticancer drugs by metallothionein....Pages 569-572
The possible role of metallothionein in cancer therapy by copper acetate....Pages 573-576
Interaction of metallothionein with the carcinogenic metals Ni(II), Cr(VI) and As(III)....Pages 577-580
A novel metallothionein gene therapy approach for chemo-and radio-protection....Pages 581-584
Metallothionein immunostaining as a prognostic indicator in canine mammary tumours....Pages 585-594
Metallothionein isoform gene expression in four human bladder cancer cell lines....Pages 595-600
The suppression of metallothionein synthesis inhibits the growth of leukemia P388 cells....Pages 601-606
Front Matter....Pages 607-612
Identification and characterisation of metallothioneins from environmental indicator species as potential biomonitors....Pages 613-617
Assessment of metal exposure of marine edible mussels by means of a biomarker....Pages 619-619
Metallothionein level estimation in the bioassay method for water quality assessment in freshwater reservoirs polluted by waste waters....Pages 621-627
Back Matter....Pages 629-632
....Pages 633-640