Ebook: ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer

This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA.
This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.

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Content:
Front Matter....Pages i-3
Poly ADP-ribosylation: A DNA break signal mechanism....Pages 5-11
Measurement of poly(ADP-ribose) glycohydrolase activity by high resolution polyacrylamide gel electrophoresis: Specific inhibition by histones and nuclear matrix proteins....Pages 13-18
Regulatory mechanisms of poly(ADP-ribose) polymerase....Pages 19-22
Poly(ADP-ribose) polymerase: A guardian of the genome that facilitates DNA repair by protecting against DNA recombination....Pages 23-30
Clostridial toxins: Molecular probes of Rho-dependent signaling and apoptosis....Pages 31-35
Role of brefeldin A-dependent ADP-ribosylation in the control of intracellular membrane transport....Pages 37-42
A dual approach in the study of poly (ADP-ribose) polymerase: In vitro random mutagenesis and generation of deficient mice....Pages 43-51
The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse....Pages 53-60
Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis....Pages 61-68
Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase....Pages 69-74
Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment....Pages 75-81
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes....Pages 83-87
Identification of the archaeal NMN adenylyltransferase gene....Pages 89-98
Characterization of NAD:arginine ADP-ribosyltransferases....Pages 99-102
The CD38-cyclic ADP-ribose signaling system in insulin secretion....Pages 103-107
Newly discovered anti-inflammatory properties of the benzamides and nicotinamides....Pages 109-113
Poly(ADP-ribose) turnover in quail myoblast cells: Relation between the polymer level and its catabolism by glycohydrolase....Pages 115-118
Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication....Pages 119-125
Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice....Pages 127-135
Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors....Pages 137-148
Back Matter....Pages 149-152
....Pages 153-157