Ebook: Metallopharmaceuticals I: DNA Interactions

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

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Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

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Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.
Content:
Front Matter....Pages I-XI
Anticancer Activity of Cisplatin and Related Complexes....Pages 1-43
Development of an Orally Active Platinum Anticancer Drug: JM216....Pages 45-71
trans-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs....Pages 73-98
Chemistry and Biology of Multifunctional DNA Binding Agents....Pages 99-115
Role of Metal Ions in Antisense and Antigene Strategies....Pages 117-142
Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumour Metastases....Pages 143-169
Non-Platinum Antitumor Compounds....Pages 171-199

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Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.
Content:
Front Matter....Pages I-XI
Anticancer Activity of Cisplatin and Related Complexes....Pages 1-43
Development of an Orally Active Platinum Anticancer Drug: JM216....Pages 45-71
trans-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs....Pages 73-98
Chemistry and Biology of Multifunctional DNA Binding Agents....Pages 99-115
Role of Metal Ions in Antisense and Antigene Strategies....Pages 117-142
Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumour Metastases....Pages 143-169
Non-Platinum Antitumor Compounds....Pages 171-199
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