Ebook: Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.

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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.
Content:
Front Matter....Pages i-viii
The Fate of Xenobiotics in the Body....Pages 1-20
Protein-Protein Interactions in the P450 Monooxygenase System....Pages 21-39
Structures of Mitochondrial P450 System Proteins....Pages 41-54
Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs)....Pages 55-70
Expression and Regulation of Flavin-Containing Monooxygenases....Pages 71-79
Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism....Pages 81-90
Pharmacogenetics Polymorphisms in Xenobiotic Metabolism....Pages 91-110
Clinical Aspects of Polymorphic Drug Metabolism in Humans....Pages 111-126
Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and of Glutathione S-Transferase Ml and Cancer Susceptibility in the Human....Pages 127-143
Cytochrome P450 Isoforms....Pages 145-155
Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals....Pages 157-172
The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity....Pages 173-182
Importance of Drug Metabolism in Drug Discovery and Development....Pages 183-193
Aflatoxin Biotransformation and Toxicology....Pages 195-209
Role of Individual Enzymes in the Control of Genotoxic Metabolites....Pages 211-220
Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and its Reduction by Xenobiotic Interaction....Pages 221-246
Cytochrome P4501A1 (CYP 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay....Pages 247-257
CYP 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents....Pages 259-270
The Biochemistry And Physiology of Prostacyclin- and Thromboxane-Synthase....Pages 271-282
Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment....Pages 283-291
Back Matter....Pages 293-294

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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.
Content:
Front Matter....Pages i-viii
The Fate of Xenobiotics in the Body....Pages 1-20
Protein-Protein Interactions in the P450 Monooxygenase System....Pages 21-39
Structures of Mitochondrial P450 System Proteins....Pages 41-54
Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs)....Pages 55-70
Expression and Regulation of Flavin-Containing Monooxygenases....Pages 71-79
Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism....Pages 81-90
Pharmacogenetics Polymorphisms in Xenobiotic Metabolism....Pages 91-110
Clinical Aspects of Polymorphic Drug Metabolism in Humans....Pages 111-126
Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and of Glutathione S-Transferase Ml and Cancer Susceptibility in the Human....Pages 127-143
Cytochrome P450 Isoforms....Pages 145-155
Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals....Pages 157-172
The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity....Pages 173-182
Importance of Drug Metabolism in Drug Discovery and Development....Pages 183-193
Aflatoxin Biotransformation and Toxicology....Pages 195-209
Role of Individual Enzymes in the Control of Genotoxic Metabolites....Pages 211-220
Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and its Reduction by Xenobiotic Interaction....Pages 221-246
Cytochrome P4501A1 (CYP 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay....Pages 247-257
CYP 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents....Pages 259-270
The Biochemistry And Physiology of Prostacyclin- and Thromboxane-Synthase....Pages 271-282
Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment....Pages 283-291
Back Matter....Pages 293-294
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